Dermatologic Uses of Methotrexate in Children: Indications and Guidelines

Amy S. Paller*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Abstract: Although methotrexate is frequently employed as an antimetabolic chemotherapeutic agent for childhood cancer, it is rarely used for dermatologic disorders in children. In the pediatrie patient whose skin disease is recalcitrant to more conservative treatment, a trial of methotrexate is often appropriate. There are few reports of the drug's use for skin disorders in childhood upon which to base rational therapeutic management, however. In setting guidelines for use in children, we must consider pharmacokinetic studies and methotrexate toxicity observed in managing pediatric cancer.

Original languageEnglish (US)
Pages (from-to)238-243
Number of pages6
JournalPediatric Dermatology
Issue number3
StatePublished - Jan 1 1985

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Dermatology


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