Des-tyrosine-γ-endorphin: H-reflex response similar to neuroleptics

John Metz; Daniel A. Busch; Herbert Y. Meltzer

doi:10.1016/0024-3205(81)90647-0

Des-tyrosine-γ-endorphin: H-reflex response similar to neuroleptics

John Metz^*, Daniel A. Busch, Herbert Y. Meltzer

^*Corresponding author for this work

Psychiatry and Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

In a study of eight schizophrenic patients, des-tyrosine-γ-endorphin was found to significantly reduce secondary facilitation of the H-reflex recovery curve. This result is similar to the effect found after treatment with classical neuroleptic medication. The effect is different from that produced by lithium carbonate or anti-depressants. This suggests that des-tyrosine-γ-endorphin and neuroleptics have a similar pharmacological action in man.

Original language	English (US)
Pages (from-to)	2003-2008
Number of pages	6
Journal	Life Sciences
Volume	28
Issue number	18
DOIs	https://doi.org/10.1016/0024-3205(81)90647-0
State	Published - May 4 1981

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Pharmacology, Toxicology and Pharmaceutics(all)

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title = "Des-tyrosine-γ-endorphin: H-reflex response similar to neuroleptics",

abstract = "In a study of eight schizophrenic patients, des-tyrosine-γ-endorphin was found to significantly reduce secondary facilitation of the H-reflex recovery curve. This result is similar to the effect found after treatment with classical neuroleptic medication. The effect is different from that produced by lithium carbonate or anti-depressants. This suggests that des-tyrosine-γ-endorphin and neuroleptics have a similar pharmacological action in man.",

author = "John Metz and Busch, {Daniel A.} and Meltzer, {Herbert Y.}",

note = "Funding Information: Supported in part by USPHS MH30938. by Organon, Inc. The assistance of Max rink, UTyE is greatly appreciated. HYM is recipient NH47,808.",

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AU - Busch, Daniel A.

AU - Meltzer, Herbert Y.

N1 - Funding Information: Supported in part by USPHS MH30938. by Organon, Inc. The assistance of Max rink, UTyE is greatly appreciated. HYM is recipient NH47,808.

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N2 - In a study of eight schizophrenic patients, des-tyrosine-γ-endorphin was found to significantly reduce secondary facilitation of the H-reflex recovery curve. This result is similar to the effect found after treatment with classical neuroleptic medication. The effect is different from that produced by lithium carbonate or anti-depressants. This suggests that des-tyrosine-γ-endorphin and neuroleptics have a similar pharmacological action in man.

AB - In a study of eight schizophrenic patients, des-tyrosine-γ-endorphin was found to significantly reduce secondary facilitation of the H-reflex recovery curve. This result is similar to the effect found after treatment with classical neuroleptic medication. The effect is different from that produced by lithium carbonate or anti-depressants. This suggests that des-tyrosine-γ-endorphin and neuroleptics have a similar pharmacological action in man.

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Des-tyrosine-γ-endorphin: H-reflex response similar to neuroleptics

Abstract

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