Des-tyrosine-γ-endorphin: H-reflex response similar to neuroleptics

John Metz*, Daniel A. Busch, Herbert Y. Meltzer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


In a study of eight schizophrenic patients, des-tyrosine-γ-endorphin was found to significantly reduce secondary facilitation of the H-reflex recovery curve. This result is similar to the effect found after treatment with classical neuroleptic medication. The effect is different from that produced by lithium carbonate or anti-depressants. This suggests that des-tyrosine-γ-endorphin and neuroleptics have a similar pharmacological action in man.

Original languageEnglish (US)
Pages (from-to)2003-2008
Number of pages6
JournalLife Sciences
Issue number18
StatePublished - May 4 1981

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)


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