Descemet stripping endothelial keratoplasty for the treatment of combined fuchs corneal endothelial dystrophy and keratoconus

Samir Vira*, Usiwoma Abugo, Carolyn Y. Shih, Ira J. Udell, Brian Sperling, Sadeer B. Hannush, Surendra Basti, Charles S. Bouchard

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


PURPOSE:: To report the first case series of patients with Fuchs corneal endothelial dystrophy (FCD) and keratoconus (KCN) who underwent Descemet stripping endothelial keratoplasty (DSEK). METHODS:: This is a retrospective case series of 6 eyes of 4 patients with combined FCD and KCN who underwent DSEK at 3 different centers. Clinical information collected included corneal topography measurements, central corneal thickness, and endothelial cell count. Visual outcomes and change in keratometric measurements were evaluated. RESULTS:: The follow-up for patients ranged from 10 to 72 months. The best-corrected visual acuity was 20/40 or better in all 6 eyes. The mean keratometric measurements decreased in all cases (range of 0.5-5.8 diopters); however, topography still demonstrated an inferior steepening in each case. CONCLUSIONS:: Patients with FCD and KCN have been previously reported as being managed with penetrating keratoplasty. We present 6 eyes of 4 patients who were managed with DSEK for the FCD. Topographically, the characteristic inferior steepening of KCN did not change; however, all patients with DSEK had flatter postoperative keratometric measurements with improved visual acuity. If a DSEK is performed for FCD before apical corneal scarring from KCN, a good visual outcome may be achieved.

Original languageEnglish (US)
Pages (from-to)1-5
Number of pages5
Issue number1
StatePublished - Jan 1 2014


  • DSEK
  • Descemet stripping automated endothelial keratoplasty
  • Fuchs endothelial dystrophy
  • PKP
  • cataract surgery
  • cornea transplant
  • keratoconus
  • keratometry
  • penetrating keratoplasty

ASJC Scopus subject areas

  • Ophthalmology

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