Design and implementation of a highly selective minimal self-replicating system

Eleftherios Kassianidis*, Douglas Philp

*Corresponding author for this work

Research output: Contribution to journalArticle

59 Scopus citations

Abstract

Self-direction: A rationally designed self-complementary template (see picture) is capable of replication, thereby amplifying itself from a reaction mixture to the exclusion of its diastereomer. This approach allows a highly selective amplification by focusing on templates that display a high level of complementarity to transition states. (Figure Presented).

Original languageEnglish (US)
Pages (from-to)6344-6348
Number of pages5
JournalAngewandte Chemie - International Edition
Volume45
Issue number38
DOIs
StatePublished - Sep 25 2006

Keywords

  • Kinetics
  • Molecular modeling
  • Self-replication
  • Supramolecular chemistry
  • Template synthesis

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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