Design and synthesis of readily degradable acyloxysilane dendrimers

Christopher M. Downing, Michael N. Missaghi, Mayfair C. Kung, Harold H. Kung*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Two types of dendrimers with AB2 branching, one with acyloxysilanes at the branching position (V type) and the other at the non-branching position (Y type), were synthesized using hydrosilylation with chlorosilanes followed by heterofunctional condensation with olefin-functional carboxylic acids, and examined as readily degradable template materials. The V type dendrimer was much more susceptible to ligand redistribution with chlorosilanes during preparation, whereas the Y type was less. The acyloxysilane linkages in these dendrimers could be cleaved readily by alcoholysis or hydrolysis on demand, making for suitable templates.

Original languageEnglish (US)
Pages (from-to)7502-7509
Number of pages8
Issue number39
StatePublished - Sep 30 2011


  • Acyloxysilane
  • Degradable dendrimer
  • Ligand redistribution

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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