Design of a MRI-visible and radiopaque drug delivery coating for bioresorbable stents

Amy C. Goodfriend, Tré R. Welch, Jian Wang, Kytai T. Nguyen, Romaine F. Johnson, Chet C. Xu, Surendranath R.Veeram Reddy, Alan Nugent, James Richardson, Joseph M. Forbess

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Cardiovascular stents are currently being used for intraluminal stenting of the trachea for tracheomalacia treatment. These devices composed of permanent materials are controversial due to their limitations at internal reinforcement and biocompatibility, especially in pediatrics. We show in a pediatric tracheomalacia rabbit model, a poly-L-lactic acid (PLLA) Double Opposed Helical bioresorbable stent (DH) elicits a more mild inflammatory response in the malacic airway compared to a control metal stent. To further improve efficacy, a multi-drug delivery, bioresorbable coating was designed. The coating design controllably delivers ciprofloxacin (antibiotic) for one week and dexamethasone (anti-inflammatory agent) for three months. The bioresorbable polymeric components also demonstrate feasible visibility utilizing Magnetic Resonance Imaging (MRI). The local multidrug delivery and imaging capabilities in this coating design in combination with the bioresorbable DH stent will result in successful intervention specifically design for pediatric tracheomalacia. This design will eliminate long-term risks associated with current permanent devices and provide necessary theranostic agents to facilitate healing and monitor progress via non-invasive imaging techniques.

Original languageEnglish (US)
Title of host publicationBiomedical and Biotechnology Engineering
PublisherAmerican Society of Mechanical Engineers (ASME)
ISBN (Electronic)9780791857380
DOIs
StatePublished - Jan 1 2015
EventASME 2015 International Mechanical Engineering Congress and Exposition, IMECE 2015 - Houston, United States
Duration: Nov 13 2015Nov 19 2015

Publication series

NameASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE)
Volume3-2015

Conference

ConferenceASME 2015 International Mechanical Engineering Congress and Exposition, IMECE 2015
CountryUnited States
CityHouston
Period11/13/1511/19/15

Fingerprint

Stents
Drug delivery
Pediatrics
Coatings
Imaging techniques
Antibiotics
Lactic acid
Biocompatibility
Visibility
Reinforcement
Magnetic Resonance Imaging
Metals

ASJC Scopus subject areas

  • Mechanical Engineering

Cite this

Goodfriend, A. C., Welch, T. R., Wang, J., Nguyen, K. T., Johnson, R. F., Xu, C. C., ... Forbess, J. M. (2015). Design of a MRI-visible and radiopaque drug delivery coating for bioresorbable stents. In Biomedical and Biotechnology Engineering (ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE); Vol. 3-2015). American Society of Mechanical Engineers (ASME). https://doi.org/10.1115/IMECE2015-52146
Goodfriend, Amy C. ; Welch, Tré R. ; Wang, Jian ; Nguyen, Kytai T. ; Johnson, Romaine F. ; Xu, Chet C. ; Reddy, Surendranath R.Veeram ; Nugent, Alan ; Richardson, James ; Forbess, Joseph M. / Design of a MRI-visible and radiopaque drug delivery coating for bioresorbable stents. Biomedical and Biotechnology Engineering. American Society of Mechanical Engineers (ASME), 2015. (ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE)).
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abstract = "Cardiovascular stents are currently being used for intraluminal stenting of the trachea for tracheomalacia treatment. These devices composed of permanent materials are controversial due to their limitations at internal reinforcement and biocompatibility, especially in pediatrics. We show in a pediatric tracheomalacia rabbit model, a poly-L-lactic acid (PLLA) Double Opposed Helical bioresorbable stent (DH) elicits a more mild inflammatory response in the malacic airway compared to a control metal stent. To further improve efficacy, a multi-drug delivery, bioresorbable coating was designed. The coating design controllably delivers ciprofloxacin (antibiotic) for one week and dexamethasone (anti-inflammatory agent) for three months. The bioresorbable polymeric components also demonstrate feasible visibility utilizing Magnetic Resonance Imaging (MRI). The local multidrug delivery and imaging capabilities in this coating design in combination with the bioresorbable DH stent will result in successful intervention specifically design for pediatric tracheomalacia. This design will eliminate long-term risks associated with current permanent devices and provide necessary theranostic agents to facilitate healing and monitor progress via non-invasive imaging techniques.",
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Goodfriend, AC, Welch, TR, Wang, J, Nguyen, KT, Johnson, RF, Xu, CC, Reddy, SRV, Nugent, A, Richardson, J & Forbess, JM 2015, Design of a MRI-visible and radiopaque drug delivery coating for bioresorbable stents. in Biomedical and Biotechnology Engineering. ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE), vol. 3-2015, American Society of Mechanical Engineers (ASME), ASME 2015 International Mechanical Engineering Congress and Exposition, IMECE 2015, Houston, United States, 11/13/15. https://doi.org/10.1115/IMECE2015-52146

Design of a MRI-visible and radiopaque drug delivery coating for bioresorbable stents. / Goodfriend, Amy C.; Welch, Tré R.; Wang, Jian; Nguyen, Kytai T.; Johnson, Romaine F.; Xu, Chet C.; Reddy, Surendranath R.Veeram; Nugent, Alan; Richardson, James; Forbess, Joseph M.

Biomedical and Biotechnology Engineering. American Society of Mechanical Engineers (ASME), 2015. (ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE); Vol. 3-2015).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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AB - Cardiovascular stents are currently being used for intraluminal stenting of the trachea for tracheomalacia treatment. These devices composed of permanent materials are controversial due to their limitations at internal reinforcement and biocompatibility, especially in pediatrics. We show in a pediatric tracheomalacia rabbit model, a poly-L-lactic acid (PLLA) Double Opposed Helical bioresorbable stent (DH) elicits a more mild inflammatory response in the malacic airway compared to a control metal stent. To further improve efficacy, a multi-drug delivery, bioresorbable coating was designed. The coating design controllably delivers ciprofloxacin (antibiotic) for one week and dexamethasone (anti-inflammatory agent) for three months. The bioresorbable polymeric components also demonstrate feasible visibility utilizing Magnetic Resonance Imaging (MRI). The local multidrug delivery and imaging capabilities in this coating design in combination with the bioresorbable DH stent will result in successful intervention specifically design for pediatric tracheomalacia. This design will eliminate long-term risks associated with current permanent devices and provide necessary theranostic agents to facilitate healing and monitor progress via non-invasive imaging techniques.

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BT - Biomedical and Biotechnology Engineering

PB - American Society of Mechanical Engineers (ASME)

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Goodfriend AC, Welch TR, Wang J, Nguyen KT, Johnson RF, Xu CC et al. Design of a MRI-visible and radiopaque drug delivery coating for bioresorbable stents. In Biomedical and Biotechnology Engineering. American Society of Mechanical Engineers (ASME). 2015. (ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE)). https://doi.org/10.1115/IMECE2015-52146