Design of a multicenter, double-blind study to assess the effects of prophylactic diltiazem on early reinfarction after non-Q-wave acute myocardial infarction: Diltiazem reinfarction study

Craig M. Pratt; Robert Gibson; William Boden; Pierre Theroux; Hans Strauss; Mihai Gheorghiade; Robert Capone; Michael Crawford; Robert Schlant; Daniel Arensberg; Robert Kleiger; M. Benjamin Perryman; Kenneth Schechtman; Phillip Young; Robert Roberts

doi:10.1016/S0002-9149(86)80008-X

Design of a multicenter, double-blind study to assess the effects of prophylactic diltiazem on early reinfarction after non-Q-wave acute myocardial infarction: Diltiazem reinfarction study

Craig M. Pratt, Robert Gibson, William Boden, Pierre Theroux, Hans Strauss, Mihai Gheorghiade, Robert Capone, Michael Crawford, Robert Schlant, Daniel Arensberg, Robert Kleiger, M. Benjamin Perryman, Kenneth Schechtman, Phillip Young, Robert Roberts

Medicine, Cardiology Division

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

This protocol describes the design of an international study to examine the potential prophylactic effect of 14 days of diltiazem therapy to prevent early reinfarction in patients initially presenting with non-Q-wave acute myocardial infarction. Reinfarction was defined by the detection of a secondary elevation of plasma MB-creatine kinase. The results of clinical trials, instrumental in this protocol design, that established the increased propensity for early reinfarction after initial non-Q-wave infarction are described and the implications of the present study are discussed.

Original language	English (US)
Pages (from-to)	906-910
Number of pages	5
Journal	The American journal of cardiology
Volume	58
Issue number	10
DOIs	https://doi.org/10.1016/S0002-9149(86)80008-X
State	Published - Nov 1 1986

Funding

Participating institutions and personnel are listed in the Appendix. This study is supported by a grant from Marion Laboratories, Inc., Kansas City, Missouri. Manuscript received April 23, 1986; revised manuscript received July 7, 1986, accepted July 8, 1986.

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0002-9149(86)80008-X

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Pratt, C. M., Gibson, R., Boden, W., Theroux, P., Strauss, H., Gheorghiade, M., Capone, R., Crawford, M., Schlant, R., Arensberg, D., Kleiger, R., Benjamin Perryman, M., Schechtman, K., Young, P., & Roberts, R. (1986). Design of a multicenter, double-blind study to assess the effects of prophylactic diltiazem on early reinfarction after non-Q-wave acute myocardial infarction: Diltiazem reinfarction study. The American journal of cardiology, 58(10), 906-910. https://doi.org/10.1016/S0002-9149(86)80008-X

@article{e00042c151054bb3bd88f48695e3a443,

title = "Design of a multicenter, double-blind study to assess the effects of prophylactic diltiazem on early reinfarction after non-Q-wave acute myocardial infarction: Diltiazem reinfarction study",

abstract = "This protocol describes the design of an international study to examine the potential prophylactic effect of 14 days of diltiazem therapy to prevent early reinfarction in patients initially presenting with non-Q-wave acute myocardial infarction. Reinfarction was defined by the detection of a secondary elevation of plasma MB-creatine kinase. The results of clinical trials, instrumental in this protocol design, that established the increased propensity for early reinfarction after initial non-Q-wave infarction are described and the implications of the present study are discussed.",

author = "Pratt, {Craig M.} and Robert Gibson and William Boden and Pierre Theroux and Hans Strauss and Mihai Gheorghiade and Robert Capone and Michael Crawford and Robert Schlant and Daniel Arensberg and Robert Kleiger and {Benjamin Perryman}, M. and Kenneth Schechtman and Phillip Young and Robert Roberts",

note = "Funding Information: Participating institutions and personnel are listed in the Appendix. This study is supported by a grant from Marion Laboratories, Inc., Kansas City, Missouri. Manuscript received April 23, 1986; revised manuscript received July 7, 1986, accepted July 8, 1986.",

year = "1986",

month = nov,

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doi = "10.1016/S0002-9149(86)80008-X",

language = "English (US)",

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pages = "906--910",

journal = "The American journal of cardiology",

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Pratt, CM, Gibson, R, Boden, W, Theroux, P, Strauss, H, Gheorghiade, M, Capone, R, Crawford, M, Schlant, R, Arensberg, D, Kleiger, R, Benjamin Perryman, M, Schechtman, K, Young, P & Roberts, R 1986, 'Design of a multicenter, double-blind study to assess the effects of prophylactic diltiazem on early reinfarction after non-Q-wave acute myocardial infarction: Diltiazem reinfarction study', The American journal of cardiology, vol. 58, no. 10, pp. 906-910. https://doi.org/10.1016/S0002-9149(86)80008-X

Design of a multicenter, double-blind study to assess the effects of prophylactic diltiazem on early reinfarction after non-Q-wave acute myocardial infarction: Diltiazem reinfarction study. / Pratt, Craig M.; Gibson, Robert; Boden, William et al.
In: The American journal of cardiology, Vol. 58, No. 10, 01.11.1986, p. 906-910.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Design of a multicenter, double-blind study to assess the effects of prophylactic diltiazem on early reinfarction after non-Q-wave acute myocardial infarction

T2 - Diltiazem reinfarction study

AU - Pratt, Craig M.

AU - Gibson, Robert

AU - Boden, William

AU - Theroux, Pierre

AU - Strauss, Hans

AU - Gheorghiade, Mihai

AU - Capone, Robert

AU - Crawford, Michael

AU - Schlant, Robert

AU - Arensberg, Daniel

AU - Kleiger, Robert

AU - Benjamin Perryman, M.

AU - Schechtman, Kenneth

AU - Young, Phillip

AU - Roberts, Robert

N1 - Funding Information: Participating institutions and personnel are listed in the Appendix. This study is supported by a grant from Marion Laboratories, Inc., Kansas City, Missouri. Manuscript received April 23, 1986; revised manuscript received July 7, 1986, accepted July 8, 1986.

PY - 1986/11/1

Y1 - 1986/11/1

N2 - This protocol describes the design of an international study to examine the potential prophylactic effect of 14 days of diltiazem therapy to prevent early reinfarction in patients initially presenting with non-Q-wave acute myocardial infarction. Reinfarction was defined by the detection of a secondary elevation of plasma MB-creatine kinase. The results of clinical trials, instrumental in this protocol design, that established the increased propensity for early reinfarction after initial non-Q-wave infarction are described and the implications of the present study are discussed.

AB - This protocol describes the design of an international study to examine the potential prophylactic effect of 14 days of diltiazem therapy to prevent early reinfarction in patients initially presenting with non-Q-wave acute myocardial infarction. Reinfarction was defined by the detection of a secondary elevation of plasma MB-creatine kinase. The results of clinical trials, instrumental in this protocol design, that established the increased propensity for early reinfarction after initial non-Q-wave infarction are described and the implications of the present study are discussed.

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ER -

Design of a multicenter, double-blind study to assess the effects of prophylactic diltiazem on early reinfarction after non-Q-wave acute myocardial infarction: Diltiazem reinfarction study

Abstract

Funding

ASJC Scopus subject areas

UN SDGs

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