Design of molecular logic devices based on a programmable DNA-regulated semisynthetic enzyme

Nathan C. Gianneschi*, M. Reza Ghadiri

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

60 Scopus citations

Abstract

Informed decisions: Logic operations (AND, OR, NOR) can be performed with an enzyme by tagging it and its inhibitor with single-strand DNA. By adding appropriate single-strand DNA, the activity of the enzyme complex can be switched ON and OFF (see picture for NOR logic; DE: DNA-tagged enzyme; DI 1, DI2: DNA-tagged inhibitors), or it can be used as a sensitive PCR-independent gene-diagnostic probe. (Chemical Equation Presented).

Original languageEnglish (US)
Pages (from-to)3955-3958
Number of pages4
JournalAngewandte Chemie - International Edition
Volume46
Issue number21
DOIs
StatePublished - 2007

Keywords

  • DNA
  • Enzymes
  • Logic gates
  • Molecular devices
  • Sensors

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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