Design of molecular logic devices based on a programmable DNA-regulated semisynthetic enzyme

Nathan C. Gianneschi; M. Reza Ghadiri

doi:10.1002/anie.200700047

Design of molecular logic devices based on a programmable DNA-regulated semisynthetic enzyme

Nathan C. Gianneschi^*, M. Reza Ghadiri

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

67 Scopus citations

Abstract

Informed decisions: Logic operations (AND, OR, NOR) can be performed with an enzyme by tagging it and its inhibitor with single-strand DNA. By adding appropriate single-strand DNA, the activity of the enzyme complex can be switched ON and OFF (see picture for NOR logic; DE: DNA-tagged enzyme; DI ¹, DI²: DNA-tagged inhibitors), or it can be used as a sensitive PCR-independent gene-diagnostic probe. (Chemical Equation Presented).

Original language	English (US)
Pages (from-to)	3955-3958
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	46
Issue number	21
DOIs	https://doi.org/10.1002/anie.200700047
State	Published - 2007

Funding

Keywords

DNA
Enzymes
Logic gates
Molecular devices
Sensors

ASJC Scopus subject areas

General Chemistry
Catalysis

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10.1002/anie.200700047

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KW - Logic gates

KW - Molecular devices

KW - Sensors

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Design of molecular logic devices based on a programmable DNA-regulated semisynthetic enzyme

Abstract

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Keywords

ASJC Scopus subject areas

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