Design of Novel Mixer and Applicator for Two-Component Surgical Adhesives

Kevin Go, Yeong Kim, Andy H. Lee, Kelly Staricha*, Phillip Messersmith, Matthew Glucksberg

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Furthermore, in these devices a significant amount of adhesive iswasted during the application process, as material within the dead space of the mixing chamber must be discarded. We have designed and demonstrated a new active mixer and applicator system capable of rapidly and efficiently mixing two components of an adhesive and applying it to the surgical site. Recently, Messersmith et al. have developed a tissue adhesive inspired by the mussel byssus and have shown that it is effective as a surgical sealant, and is especially suited for wet environments such as in fetal surgery. Like some other tissue sealants, this one requires that two components of differing viscosities be thoroughly mixed within a specified and short time period. Through a combination of compression and shear testing, we demonstrated that our device could effectively mix the adhesive developed by Messersmith et al. and improve its shear strength to significantly higher values than what has been reported for vortex mixing. Overall, our mixer and applicator system not only has potential applications in mixing and applying various adhesives in multiple surgical fields but also makes this particular adhesive viable for clinical use.

Original languageEnglish (US)
Article number045001
JournalJournal of Medical Devices, Transactions of the ASME
Volume9
Issue number4
DOIs
StatePublished - Jun 8 2015

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biomedical Engineering

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