Design of scytalone dehydratase inhibitors as rice blast fungicides: Derivatives of norephedrine

Gregory S. Basarab; Douglas B. Jordan; Troy C. Gehret; Rand S. Schwartz; Zdzislaw Wawrzak

doi:10.1016/S0960-894X(99)00247-4

Design of scytalone dehydratase inhibitors as rice blast fungicides: Derivatives of norephedrine

Gregory S. Basarab^*, Douglas B. Jordan, Troy C. Gehret, Rand S. Schwartz, Zdzislaw Wawrzak

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Five X-ray crystal structures of scytalone dehydratase complexed with different inhibitors have delineated conformationally flexible regions of the binding pocket. This information was used for the design and synthesis of a norephedrine-derived cyanoacetamide class of inhibitors leading to potent fungicides.

Original language	English (US)
Pages (from-to)	1613-1618
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	9
Issue number	11
DOIs	https://doi.org/10.1016/S0960-894X(99)00247-4
State	Published - Jun 7 1999

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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abstract = "Five X-ray crystal structures of scytalone dehydratase complexed with different inhibitors have delineated conformationally flexible regions of the binding pocket. This information was used for the design and synthesis of a norephedrine-derived cyanoacetamide class of inhibitors leading to potent fungicides.",

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AU - Schwartz, Rand S.

AU - Wawrzak, Zdzislaw

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AB - Five X-ray crystal structures of scytalone dehydratase complexed with different inhibitors have delineated conformationally flexible regions of the binding pocket. This information was used for the design and synthesis of a norephedrine-derived cyanoacetamide class of inhibitors leading to potent fungicides.

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Design of scytalone dehydratase inhibitors as rice blast fungicides: Derivatives of norephedrine

Abstract

ASJC Scopus subject areas

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