Design of scytalone dehydratase inhibitors as rice blast fungicides: Derivatives of norephedrine

Gregory S. Basarab*, Douglas B. Jordan, Troy C. Gehret, Rand S. Schwartz, Zdzislaw Wawrzak

*Corresponding author for this work

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

Five X-ray crystal structures of scytalone dehydratase complexed with different inhibitors have delineated conformationally flexible regions of the binding pocket. This information was used for the design and synthesis of a norephedrine-derived cyanoacetamide class of inhibitors leading to potent fungicides.

Original languageEnglish (US)
Pages (from-to)1613-1618
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume9
Issue number11
DOIs
StatePublished - Jun 7 1999

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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