Design of scytalone dehydratase inhibitors as rice blast fungicides: Derivatives of norephedrine

Gregory S. Basarab*, Douglas B. Jordan, Troy C. Gehret, Rand S. Schwartz, Zdzislaw Wawrzak

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    29 Scopus citations

    Abstract

    Five X-ray crystal structures of scytalone dehydratase complexed with different inhibitors have delineated conformationally flexible regions of the binding pocket. This information was used for the design and synthesis of a norephedrine-derived cyanoacetamide class of inhibitors leading to potent fungicides.

    Original languageEnglish (US)
    Pages (from-to)1613-1618
    Number of pages6
    JournalBioorganic and Medicinal Chemistry Letters
    Volume9
    Issue number11
    DOIs
    StatePublished - Jun 7 1999

    ASJC Scopus subject areas

    • Biochemistry
    • Molecular Medicine
    • Molecular Biology
    • Pharmaceutical Science
    • Drug Discovery
    • Clinical Biochemistry
    • Organic Chemistry

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