Design of scytalone dehydratase inhibitors as rice blast fungicides: (N- phenoxypropyl)-carboxamides

Douglas B. Jordan*, Thomas A. Lessen, Zdzislaw Wawrzak, John J. Bisaha, Troy C. Gehret, Stephen L. Hansen, Rand S. Schwartz, Gregory S. Basarab

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    25 Scopus citations

    Abstract

    Insights gained from a crystal structure of scytalone dehydratase led to the design of carboxamide inhibitors with a phenoxypropyl group substituted on the nitrogen atom. Potent enzyme inhibitors were synthesized around this motif, the best of which provided excellent control of rice blast disease in greenhouse assays and outdoor field trials.

    Original languageEnglish (US)
    Pages (from-to)1607-1612
    Number of pages6
    JournalBioorganic and Medicinal Chemistry Letters
    Volume9
    Issue number11
    DOIs
    StatePublished - Jun 7 1999

    ASJC Scopus subject areas

    • Biochemistry
    • Molecular Medicine
    • Molecular Biology
    • Pharmaceutical Science
    • Drug Discovery
    • Clinical Biochemistry
    • Organic Chemistry

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