Design Rules of Hydrogen-Bonded Organic Frameworks with High Chemical and Thermal Stabilities

Xiyu Song, Yao Wang, Chen Wang, Dong Wang, Guowei Zhuang, Kent O. Kirlikovali, Peng Li*, Omar K. Farha

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations


Hydrogen-bonded organic frameworks (HOFs), self-assembled from strategically pre-designed molecular tectons with complementary hydrogen-bonding patterns, are rapidly evolving into a novel and important class of porous materials. In addition to their common features shared with other functionalized porous materials constructed from modular building blocks, the intrinsically flexible and reversible H-bonding connections endow HOFs with straightforward purification procedures, high crystallinity, solution processability, and recyclability. These unique advantages of HOFs have attracted considerable attention across a broad range of fields, including gas adsorption and separation, catalysis, chemical sensing, and electrical and optical materials. However, the relatively weak H-bonding interactions within HOFs can potentially limit their stability and potential use in further applications. To that end, this Perspective highlights recent advances in the development of chemically and thermally robust HOF materials and systematically discusses relevant design rules and synthesis strategies to access highly stable HOFs.

Original languageEnglish (US)
Pages (from-to)10663-10687
Number of pages25
JournalJournal of the American Chemical Society
Issue number24
StatePublished - Jun 22 2022

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry


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