Tropolones are promising organic compounds that can have important biologic effects. We developed a series of new 2-quinolyl-1,3-tropolones derivatives that were prepared by the acid-catalyzed reaction of 4,7-dichloro-2-methylquinolines with 1,2-benzoquinones. 2-Quinolyl-1,3-tropolones have been synthesized and tested for their anti-proliferative activity against several human cancer cell lines. Two compounds (3d and mixture B of 3i-k) showed excellent activity against six cancer cell lines of different tissue of origin. The promising compounds 3d and mixture B of 3i-k also demonstrated induction of apoptotic cell death of ovarian cancer (OVCAR-3, OVCAR-8) and colon cancer (HCT 116) cell lines and affected ERK signaling. In summary, 2-quinolyl-1,3-tropolones are promising compounds for development of effective anticancer agents. This journal is
ASJC Scopus subject areas
- Chemical Engineering(all)
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Gusakov, E. A. (Contributor), Topchu, I. A. (Contributor), Mazitova, A. M. (Contributor), Dorogan, I. V. (Contributor), Bulatov, E. R. (Contributor), Serebriiskii, I. G. (Contributor), Abramova, Z. I. (Contributor), Tupaeva, I. O. (Contributor), Demidov, O. P. (Contributor), Toan, D. N. (Contributor), Lam, T. D. (Contributor), Bang, D. N. (Contributor), Boumber, Y. (Contributor), Sayapin, Y. A. (Contributor) & Minkin, V. I. (Contributor), Cambridge Crystallographic Data Centre, 2021