Designing follicle-environment interactions with biomaterials

Rachel M. Smith; Teresa K. Woodruff; Lonnie D. Shea

doi:10.1007/978-1-4419-6518-9_2

Designing follicle-environment interactions with biomaterials

Rachel M. Smith, Teresa K. Woodruff, Lonnie D. Shea

Obstetrics and Gynecology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

22 Scopus citations

Abstract

The recruitment, selection, and ovulation of follicles, termed folliculogenesis, result from a complex set of signals that are exchanged between the follicle and its environment. These interactions include circulating hormones, extracellular matrix (ECM) components, and mechanical signaling. The ovarian environment is highly dynamic, which has been commonly characterized by the cyclic changes in endocrine factors. Disruption of this dynamic interplay between the follicle and its environment, which can result from environmental toxins, disease, or disease therapies, underlies many causes of infertility. Although the significance of endocrine factors has been widely recognized, numerous other aspects of the ovarian environment are increasingly being recognized for their role in regulating folliculogenesis. Identifying the environmental mechanisms that regulate follicle development is essential for creating novel strategies to preserve fertility.

Original language	English (US)
Title of host publication	Oncofertility
Subtitle of host publication	Ethical, Legal, Social, and Medical Perspectives
Editors	teresa Woodruff, Sarah Rodriguez, Lisa Campo-Engelstein, Laurie Zoloth
Pages	11-24
Number of pages	14
DOIs	https://doi.org/10.1007/978-1-4419-6518-9_2
State	Published - 2010

Publication series

Name	Cancer Treatment and Research
Volume	156
ISSN (Print)	0927-3042

Funding

This research was supported by the Oncofertility Consortium NIH 8UL1DE019587, 5RL1HD058296.

ASJC Scopus subject areas

Oncology
Cancer Research

Access to Document

10.1007/978-1-4419-6518-9_2

Cite this

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abstract = "The recruitment, selection, and ovulation of follicles, termed folliculogenesis, result from a complex set of signals that are exchanged between the follicle and its environment. These interactions include circulating hormones, extracellular matrix (ECM) components, and mechanical signaling. The ovarian environment is highly dynamic, which has been commonly characterized by the cyclic changes in endocrine factors. Disruption of this dynamic interplay between the follicle and its environment, which can result from environmental toxins, disease, or disease therapies, underlies many causes of infertility. Although the significance of endocrine factors has been widely recognized, numerous other aspects of the ovarian environment are increasingly being recognized for their role in regulating folliculogenesis. Identifying the environmental mechanisms that regulate follicle development is essential for creating novel strategies to preserve fertility.",

author = "Smith, {Rachel M.} and Woodruff, {Teresa K.} and Shea, {Lonnie D.}",

note = "Funding Information: This research was supported by the Oncofertility Consortium NIH 8UL1DE019587, 5RL1HD058296.",

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Designing follicle-environment interactions with biomaterials. / Smith, Rachel M.; Woodruff, Teresa K.; Shea, Lonnie D.
Oncofertility: Ethical, Legal, Social, and Medical Perspectives. ed. / teresa Woodruff; Sarah Rodriguez; Lisa Campo-Engelstein; Laurie Zoloth. 2010. p. 11-24 (Cancer Treatment and Research; Vol. 156).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

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Designing follicle-environment interactions with biomaterials

Abstract

Publication series

Funding

ASJC Scopus subject areas

Access to Document

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