Designing follicle-environment interactions with biomaterials

Rachel M. Smith, Teresa K. Woodruff, Lonnie D. Shea

Research output: Chapter in Book/Report/Conference proceedingChapter

15 Scopus citations


The recruitment, selection, and ovulation of follicles, termed folliculogenesis, result from a complex set of signals that are exchanged between the follicle and its environment. These interactions include circulating hormones, extracellular matrix (ECM) components, and mechanical signaling. The ovarian environment is highly dynamic, which has been commonly characterized by the cyclic changes in endocrine factors. Disruption of this dynamic interplay between the follicle and its environment, which can result from environmental toxins, disease, or disease therapies, underlies many causes of infertility. Although the significance of endocrine factors has been widely recognized, numerous other aspects of the ovarian environment are increasingly being recognized for their role in regulating folliculogenesis. Identifying the environmental mechanisms that regulate follicle development is essential for creating novel strategies to preserve fertility.

Original languageEnglish (US)
Title of host publicationOncofertility
Subtitle of host publicationEthical, Legal, Social, and Medical Perspectives
Editorsteresa Woodruff, Sarah Rodriguez, Lisa Campo-Engelstein, Laurie Zoloth
Number of pages14
StatePublished - Sep 13 2010

Publication series

NameCancer Treatment and Research
ISSN (Print)0927-3042

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Smith, R. M., Woodruff, T. K., & Shea, L. D. (2010). Designing follicle-environment interactions with biomaterials. In T. Woodruff, S. Rodriguez, L. Campo-Engelstein, & L. Zoloth (Eds.), Oncofertility: Ethical, Legal, Social, and Medical Perspectives (pp. 11-24). (Cancer Treatment and Research; Vol. 156).