TY - JOUR
T1 - Designing Synthetic Cationic Molecular Receptors for Alcohols
AU - Méndez, Luis
AU - Singleton, Raymond
AU - Slawin, Alexandra M Z
AU - Stoddart, J. Fraser
AU - Williams, David J.
AU - Williams, M. Kevin
PY - 1992/4
Y1 - 1992/4
N2 - The monoprotonation of diaza‐12‐crown‐6 derivatives converts these macrocycles to hosts for short‐chain alcohols; the association constant Ka is as high as 47 M−1. For the neutral diaza crown ether, on the other hand, Ka is only 1.1 M−1. X‐ray structure investigations show that the alcohol (R = Me) is held in place by two hydrogen bonds (see right). R = Me, Et, nPr, nBu; R′ = PhCH2, PhCH2CH2 (Figure Presented.)
AB - The monoprotonation of diaza‐12‐crown‐6 derivatives converts these macrocycles to hosts for short‐chain alcohols; the association constant Ka is as high as 47 M−1. For the neutral diaza crown ether, on the other hand, Ka is only 1.1 M−1. X‐ray structure investigations show that the alcohol (R = Me) is held in place by two hydrogen bonds (see right). R = Me, Et, nPr, nBu; R′ = PhCH2, PhCH2CH2 (Figure Presented.)
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U2 - 10.1002/anie.199204781
DO - 10.1002/anie.199204781
M3 - Article
AN - SCOPUS:33748233294
SN - 0570-0833
VL - 31
SP - 478
EP - 480
JO - Angewandte Chemie International Edition in English
JF - Angewandte Chemie International Edition in English
IS - 4
ER -