Designing visible-light optical coherence tomography towards clinics

Xiao Shu, Lisa Beckmann, Yuanbo Wang, Ian Rubinoff, Katie Lucy, Hiroshi Ishikawa, Gadi Wollstein, Amani A Fawzi, Joel S. Schuman, Roman V. Kuranov, Hao F Zhang*

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

Background: The capabilities of visible-light optical coherence tomography (vis-OCT) in noninvasive anatomical and functional retinal imaging have been demonstrated by multiple groups in both rodents and healthy human subjects. Translating laboratory prototypes to an integrated clinical-environment-friendly system is required to explore the full potential of vis-OCT in disease management. Methods: We developed and optimized a portable vis-OCT system for human retinal imaging in clinical settings. We acquired raster- and circular-scan images from both healthy and diseased human eyes. Results: The new vis-OCT provided high-quality retinal images of both subjects without any known eye diseases and patients with various retinal diseases, including retinal occlusive disease and diabetic retinopathy (DR) over a broad range of ages. Conclusions: A newly designed vis-OCT system is sufficiently optimized to be suited for routine patients' examinations in clinics. Vis-OCT has the potential to add new anatomical and functional imaging capabilities to ophthalmic clinical care.

Original languageEnglish (US)
Pages (from-to)769-781
Number of pages13
JournalQuantitative Imaging in Medicine and Surgery
Volume9
Issue number5
DOIs
StatePublished - Jan 1 2019

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Optical Coherence Tomography
Light
Retinal Diseases
Eye Diseases
Diabetic Retinopathy
Disease Management
Rodentia
Healthy Volunteers

Keywords

  • High resolution imaging
  • Ophthalmology
  • Optical coherence tomography (OCT)

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Shu, Xiao ; Beckmann, Lisa ; Wang, Yuanbo ; Rubinoff, Ian ; Lucy, Katie ; Ishikawa, Hiroshi ; Wollstein, Gadi ; Fawzi, Amani A ; Schuman, Joel S. ; Kuranov, Roman V. ; Zhang, Hao F. / Designing visible-light optical coherence tomography towards clinics. In: Quantitative Imaging in Medicine and Surgery. 2019 ; Vol. 9, No. 5. pp. 769-781.
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Shu, X, Beckmann, L, Wang, Y, Rubinoff, I, Lucy, K, Ishikawa, H, Wollstein, G, Fawzi, AA, Schuman, JS, Kuranov, RV & Zhang, HF 2019, 'Designing visible-light optical coherence tomography towards clinics', Quantitative Imaging in Medicine and Surgery, vol. 9, no. 5, pp. 769-781. https://doi.org/10.21037/qims.2019.05.01

Designing visible-light optical coherence tomography towards clinics. / Shu, Xiao; Beckmann, Lisa; Wang, Yuanbo; Rubinoff, Ian; Lucy, Katie; Ishikawa, Hiroshi; Wollstein, Gadi; Fawzi, Amani A; Schuman, Joel S.; Kuranov, Roman V.; Zhang, Hao F.

In: Quantitative Imaging in Medicine and Surgery, Vol. 9, No. 5, 01.01.2019, p. 769-781.

Research output: Contribution to journalArticle

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AU - Shu, Xiao

AU - Beckmann, Lisa

AU - Wang, Yuanbo

AU - Rubinoff, Ian

AU - Lucy, Katie

AU - Ishikawa, Hiroshi

AU - Wollstein, Gadi

AU - Fawzi, Amani A

AU - Schuman, Joel S.

AU - Kuranov, Roman V.

AU - Zhang, Hao F

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N2 - Background: The capabilities of visible-light optical coherence tomography (vis-OCT) in noninvasive anatomical and functional retinal imaging have been demonstrated by multiple groups in both rodents and healthy human subjects. Translating laboratory prototypes to an integrated clinical-environment-friendly system is required to explore the full potential of vis-OCT in disease management. Methods: We developed and optimized a portable vis-OCT system for human retinal imaging in clinical settings. We acquired raster- and circular-scan images from both healthy and diseased human eyes. Results: The new vis-OCT provided high-quality retinal images of both subjects without any known eye diseases and patients with various retinal diseases, including retinal occlusive disease and diabetic retinopathy (DR) over a broad range of ages. Conclusions: A newly designed vis-OCT system is sufficiently optimized to be suited for routine patients' examinations in clinics. Vis-OCT has the potential to add new anatomical and functional imaging capabilities to ophthalmic clinical care.

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