Designing visible-light optical coherence tomography towards clinics

Xiao Shu, Lisa Beckmann, Yuanbo Wang, Ian Rubinoff, Katie Lucy, Hiroshi Ishikawa, Gadi Wollstein, Amani A Fawzi, Joel S. Schuman, Roman V. Kuranov, Hao F Zhang*

*Corresponding author for this work

Research output: Contribution to journalArticle


Background: The capabilities of visible-light optical coherence tomography (vis-OCT) in noninvasive anatomical and functional retinal imaging have been demonstrated by multiple groups in both rodents and healthy human subjects. Translating laboratory prototypes to an integrated clinical-environment-friendly system is required to explore the full potential of vis-OCT in disease management. Methods: We developed and optimized a portable vis-OCT system for human retinal imaging in clinical settings. We acquired raster- and circular-scan images from both healthy and diseased human eyes. Results: The new vis-OCT provided high-quality retinal images of both subjects without any known eye diseases and patients with various retinal diseases, including retinal occlusive disease and diabetic retinopathy (DR) over a broad range of ages. Conclusions: A newly designed vis-OCT system is sufficiently optimized to be suited for routine patients' examinations in clinics. Vis-OCT has the potential to add new anatomical and functional imaging capabilities to ophthalmic clinical care.

Original languageEnglish (US)
Pages (from-to)769-781
Number of pages13
JournalQuantitative Imaging in Medicine and Surgery
Issue number5
StatePublished - Jan 1 2019



  • High resolution imaging
  • Ophthalmology
  • Optical coherence tomography (OCT)

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Shu, X., Beckmann, L., Wang, Y., Rubinoff, I., Lucy, K., Ishikawa, H., Wollstein, G., Fawzi, A. A., Schuman, J. S., Kuranov, R. V., & Zhang, H. F. (2019). Designing visible-light optical coherence tomography towards clinics. Quantitative Imaging in Medicine and Surgery, 9(5), 769-781.