Desmosomes and Hemidesmosomes

V. Todorović; K. R. Kligys; R. L. Dusek; J. C.R. Jones; Kathleen Janee Green

doi:10.1016/B978-0-12-378630-2.00472-2

Desmosomes and Hemidesmosomes

V. Todorović^*, K. R. Kligys, R. L. Dusek, J. C.R. Jones, Kathleen Janee Green

^*Corresponding author for this work

Pathology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Desmosomes and hemidesmosomes are adhesive junctions important for maintaining adherence within epithelial tissues - a function reflected in the Greek root desmo, meaning bound. Desmosomes facilitate adhesion between adjacent epithelial cells, whereas hemidesmosomes, named for their ultrastructural resemblance to half a desmosome, mediate adhesion between basal cells of epithelial tissues and the substratum. These junctions are functionally alike in their ability to couple the intermediate filament cytoskeleton to sites of cell-cell or cell-substratum contact at the plasma membrane. However, these organelles differ dramatically in their molecular composition and specialized functions.

Original language	English (US)
Title of host publication	Encyclopedia of Biological Chemistry
Subtitle of host publication	Second Edition
Publisher	Elsevier Inc
Pages	636-643
Number of pages	8
ISBN (Electronic)	9780123786319
ISBN (Print)	9780123786302
DOIs	https://doi.org/10.1016/B978-0-12-378630-2.00472-2
State	Published - Feb 15 2013

Keywords

Basement membrane
Collagens
Desmosomal cadherins
Desmosomes
Hemidesmosomes
Integrins
Intermediate filaments
Laminin-332
Plakins
Plakoglobin
Plakophilins

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1016/B978-0-12-378630-2.00472-2

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abstract = "Desmosomes and hemidesmosomes are adhesive junctions important for maintaining adherence within epithelial tissues - a function reflected in the Greek root desmo, meaning bound. Desmosomes facilitate adhesion between adjacent epithelial cells, whereas hemidesmosomes, named for their ultrastructural resemblance to half a desmosome, mediate adhesion between basal cells of epithelial tissues and the substratum. These junctions are functionally alike in their ability to couple the intermediate filament cytoskeleton to sites of cell-cell or cell-substratum contact at the plasma membrane. However, these organelles differ dramatically in their molecular composition and specialized functions.",

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AU - Todorović, V.

AU - Kligys, K. R.

AU - Dusek, R. L.

AU - Jones, J. C.R.

AU - Green, Kathleen Janee

PY - 2013/2/15

Y1 - 2013/2/15

N2 - Desmosomes and hemidesmosomes are adhesive junctions important for maintaining adherence within epithelial tissues - a function reflected in the Greek root desmo, meaning bound. Desmosomes facilitate adhesion between adjacent epithelial cells, whereas hemidesmosomes, named for their ultrastructural resemblance to half a desmosome, mediate adhesion between basal cells of epithelial tissues and the substratum. These junctions are functionally alike in their ability to couple the intermediate filament cytoskeleton to sites of cell-cell or cell-substratum contact at the plasma membrane. However, these organelles differ dramatically in their molecular composition and specialized functions.

AB - Desmosomes and hemidesmosomes are adhesive junctions important for maintaining adherence within epithelial tissues - a function reflected in the Greek root desmo, meaning bound. Desmosomes facilitate adhesion between adjacent epithelial cells, whereas hemidesmosomes, named for their ultrastructural resemblance to half a desmosome, mediate adhesion between basal cells of epithelial tissues and the substratum. These junctions are functionally alike in their ability to couple the intermediate filament cytoskeleton to sites of cell-cell or cell-substratum contact at the plasma membrane. However, these organelles differ dramatically in their molecular composition and specialized functions.

KW - Basement membrane

KW - Collagens

KW - Desmosomal cadherins

KW - Desmosomes

KW - Hemidesmosomes

KW - Integrins

KW - Intermediate filaments

KW - Laminin-332

KW - Plakins

KW - Plakoglobin

KW - Plakophilins

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AN - SCOPUS:85042762294

SN - 9780123786302

SP - 636

EP - 643

BT - Encyclopedia of Biological Chemistry

PB - Elsevier Inc

ER -

Desmosomes and Hemidesmosomes

Abstract

Keywords

ASJC Scopus subject areas

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