Detecting alterations in cell ultrastructure with optical imaging

Vadim Backman; Hariharan Subramanian; Prabhakar Pradhan; Yang Liu; Ilker Capoglu; Jeremy D. Rogers; Hemant K. Roy; Allen Taflove

doi:10.1109/IEMBS.2009.5333173

Detecting alterations in cell ultrastructure with optical imaging

Vadim Backman^*, Hariharan Subramanian, Prabhakar Pradhan, Yang Liu, Ilker Capoglu, Jeremy D. Rogers, Hemant K. Roy, Allen Taflove

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Scopus citations

Abstract

Understanding cell functioning at the nanoscale has been hampered in part by the diffraction limited resolution of optical microscopy. We developed partial wave spectroscopic (PWS) microscopy that is capable of quantifying statistical properties of cell structure at the nanoscale. Our animal and human studies demonstrated that alterations in the nanoscale cell architecture is one of the earliest events in carcinogenesis and precedes any other known morphological changes at larger length scales (i.e. microarchitecture).

Original language	English (US)
Title of host publication	Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Subtitle of host publication	Engineering the Future of Biomedicine, EMBC 2009
Publisher	IEEE Computer Society
Pages	6325-6326
Number of pages	2
ISBN (Print)	9781424432967
DOIs	https://doi.org/10.1109/IEMBS.2009.5333173
State	Published - Jan 1 2009
Event	31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009 - Minneapolis, MN, United States Duration: Sep 2 2009 → Sep 6 2009

Other

Other	31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009
Country/Territory	United States
City	Minneapolis, MN
Period	9/2/09 → 9/6/09

ASJC Scopus subject areas

Cell Biology
Developmental Biology
Biomedical Engineering
General Medicine

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10.1109/IEMBS.2009.5333173

Cite this

Backman, V., Subramanian, H., Pradhan, P., Liu, Y., Capoglu, I., Rogers, J. D., Roy, H. K., & Taflove, A. (2009). Detecting alterations in cell ultrastructure with optical imaging. In Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009 (pp. 6325-6326). Article 5333173 IEEE Computer Society. https://doi.org/10.1109/IEMBS.2009.5333173

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title = "Detecting alterations in cell ultrastructure with optical imaging",

abstract = "Understanding cell functioning at the nanoscale has been hampered in part by the diffraction limited resolution of optical microscopy. We developed partial wave spectroscopic (PWS) microscopy that is capable of quantifying statistical properties of cell structure at the nanoscale. Our animal and human studies demonstrated that alterations in the nanoscale cell architecture is one of the earliest events in carcinogenesis and precedes any other known morphological changes at larger length scales (i.e. microarchitecture).",

author = "Vadim Backman and Hariharan Subramanian and Prabhakar Pradhan and Yang Liu and Ilker Capoglu and Rogers, {Jeremy D.} and Roy, {Hemant K.} and Allen Taflove",

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doi = "10.1109/IEMBS.2009.5333173",

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booktitle = "Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society",

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Backman, V, Subramanian, H, Pradhan, P, Liu, Y, Capoglu, I, Rogers, JD, Roy, HK & Taflove, A 2009, Detecting alterations in cell ultrastructure with optical imaging. in Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009., 5333173, IEEE Computer Society, pp. 6325-6326, 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009, Minneapolis, MN, United States, 9/2/09. https://doi.org/10.1109/IEMBS.2009.5333173

Detecting alterations in cell ultrastructure with optical imaging. / Backman, Vadim; Subramanian, Hariharan; Pradhan, Prabhakar et al.
Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009. IEEE Computer Society, 2009. p. 6325-6326 5333173.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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Backman V, Subramanian H, Pradhan P, Liu Y, Capoglu I, Rogers JD et al. Detecting alterations in cell ultrastructure with optical imaging. In Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009. IEEE Computer Society. 2009. p. 6325-6326. 5333173 doi: 10.1109/IEMBS.2009.5333173

Detecting alterations in cell ultrastructure with optical imaging

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