Detecting Demyelination by PET: The Lesion as Imaging Target

Pedro Brugarolas*, Daniel S. Reich, Brian Popko

*Corresponding author for this work

Research output: Contribution to journalComment/debate

3 Scopus citations

Abstract

Noninvasive imaging of demyelination and remyelination is critical for diagnosis and clinical management of demyelinating diseases. Positron emission tomography (PET) has the potential to complement magnetic resonance imaging (MRI) by providing a quantitative measure specific to demyelination. In Brugarolas et al’s study1, we describe the development of the first PET tracer for voltage-gated K+ channels based on a clinically approved drug for multiple sclerosis that can be used for imaging demyelination in animal models.

Original languageEnglish (US)
JournalMolecular Imaging
Volume17
DOIs
StatePublished - Jul 19 2018

Keywords

  • advances in PET/SPECT probes
  • imaging in neuroscience
  • molecular imaging of neuro-degenerative diseases

ASJC Scopus subject areas

  • Biotechnology
  • Molecular Medicine
  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging
  • Condensed Matter Physics

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