@article{97c91458d7d9441597fe6a373dcfa60d,
title = "Detecting Demyelination by PET: The Lesion as Imaging Target",
abstract = "Noninvasive imaging of demyelination and remyelination is critical for diagnosis and clinical management of demyelinating diseases. Positron emission tomography (PET) has the potential to complement magnetic resonance imaging (MRI) by providing a quantitative measure specific to demyelination. In Brugarolas et al{\textquoteright}s study1, we describe the development of the first PET tracer for voltage-gated K+ channels based on a clinically approved drug for multiple sclerosis that can be used for imaging demyelination in animal models.",
keywords = "advances in PET/SPECT probes, imaging in neuroscience, molecular imaging of neuro-degenerative diseases",
author = "Pedro Brugarolas and Reich, {Daniel S.} and Brian Popko",
note = "Funding Information: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was partially supported by NIH/NIBIB K99EB020075 (P.B.), NIH/ NINDS R21NS084382 and the National Multiple Sclerosis Society through special funds from the Illinois Lottery (B.P.), an Innovation Fund Award from the Chicago Innovation Exchange (P.B. and B.P.), and the Dr. Miriam and Sheldon G. Adelson Medical Research Foundation (D.S.R. and B.P.). D.S.R. is supported by the Intramural Research Program of NINDS. Funding Information: The author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: The University of Chicago has filed a patent application related to this technology where P.B., and B.P. are listed as inventors. D.S.R. wishes to disclose funding from MRF and Vertex to develop methods for imaging demyelination using MRI. Funding Information: The work took 6 years and a large team of people, which included experts in neuroscience, animal models, synthetic chemistry, electrophysiology, and PET imaging from the University of Chicago, the University of Wisconsin at Madison, Case Western University, and the National Institutes of Health. It was supported by the National Multiple Sclerosis Society, the National Institute for Neurological Disorders and Stroke, the National Institute for Biomedical Imaging and Bioengineering, the Chicago Innovation Exchange (now known as the Polsky Center), and the Adelson Medical Research Foundation. Publisher Copyright: {\textcopyright} The Author(s) 2018.",
year = "2018",
month = jul,
day = "19",
doi = "10.1177/1536012118785471",
language = "English (US)",
volume = "17",
journal = "Molecular Imaging",
issn = "1535-3508",
publisher = "Decker Publishing",
}