Detection and identification of bioanalytes with high resolution LSPR spectroscopy and MALDI mass spectrometry

Jeffrey N. Anker; W. Paige Hall; Mary P. Lambert; Pauline T. Velasco; Milan Mrksich; William L. Klein; Richard P. Van Duyne

doi:10.1021/jp900266k

Detection and identification of bioanalytes with high resolution LSPR spectroscopy and MALDI mass spectrometry

Jeffrey N. Anker, W. Paige Hall, Mary P. Lambert, Pauline T. Velasco, Milan Mrksich, William L. Klein, Richard P. Van Duyne

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

High resolution localized surface plasmon resonance (HR-LSPR) sensors were combined with matrix assisted laser desorption ionization mass spectrometry (MALDI-MS) for the first time. LSPR sensors provide real-time label-free detection of molecular adsorption. Subsequent MALDI-MS analysis enables identification of the adsorbed molecules. This synergistic LSPR-MS approach was applied to the detection and identification of amyloid beta oligomers which play an important role in the molecular pathogenesis of Alzheimer's Disease.

Original language	English (US)
Pages (from-to)	5891-5894
Number of pages	4
Journal	Journal of Physical Chemistry C
Volume	113
Issue number	15
DOIs	https://doi.org/10.1021/jp900266k
State	Published - Apr 16 2009

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Energy(all)
Surfaces, Coatings and Films
Physical and Theoretical Chemistry

Access to Document

10.1021/jp900266k

Cite this

@article{83800d85e78349fb816ccda4ae52df98,

title = "Detection and identification of bioanalytes with high resolution LSPR spectroscopy and MALDI mass spectrometry",

abstract = "High resolution localized surface plasmon resonance (HR-LSPR) sensors were combined with matrix assisted laser desorption ionization mass spectrometry (MALDI-MS) for the first time. LSPR sensors provide real-time label-free detection of molecular adsorption. Subsequent MALDI-MS analysis enables identification of the adsorbed molecules. This synergistic LSPR-MS approach was applied to the detection and identification of amyloid beta oligomers which play an important role in the molecular pathogenesis of Alzheimer's Disease.",

author = "Anker, {Jeffrey N.} and Hall, {W. Paige} and Lambert, {Mary P.} and Velasco, {Pauline T.} and Milan Mrksich and Klein, {William L.} and {Van Duyne}, {Richard P.}",

year = "2009",

month = apr,

day = "16",

doi = "10.1021/jp900266k",

language = "English (US)",

volume = "113",

pages = "5891--5894",

journal = "Journal of Physical Chemistry C",

issn = "1932-7447",

publisher = "American Chemical Society",

number = "15",

}

TY - JOUR

T1 - Detection and identification of bioanalytes with high resolution LSPR spectroscopy and MALDI mass spectrometry

AU - Anker, Jeffrey N.

AU - Hall, W. Paige

AU - Lambert, Mary P.

AU - Velasco, Pauline T.

AU - Mrksich, Milan

AU - Klein, William L.

AU - Van Duyne, Richard P.

PY - 2009/4/16

Y1 - 2009/4/16

N2 - High resolution localized surface plasmon resonance (HR-LSPR) sensors were combined with matrix assisted laser desorption ionization mass spectrometry (MALDI-MS) for the first time. LSPR sensors provide real-time label-free detection of molecular adsorption. Subsequent MALDI-MS analysis enables identification of the adsorbed molecules. This synergistic LSPR-MS approach was applied to the detection and identification of amyloid beta oligomers which play an important role in the molecular pathogenesis of Alzheimer's Disease.

AB - High resolution localized surface plasmon resonance (HR-LSPR) sensors were combined with matrix assisted laser desorption ionization mass spectrometry (MALDI-MS) for the first time. LSPR sensors provide real-time label-free detection of molecular adsorption. Subsequent MALDI-MS analysis enables identification of the adsorbed molecules. This synergistic LSPR-MS approach was applied to the detection and identification of amyloid beta oligomers which play an important role in the molecular pathogenesis of Alzheimer's Disease.

UR - http://www.scopus.com/inward/record.url?scp=65249185742&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=65249185742&partnerID=8YFLogxK

U2 - 10.1021/jp900266k

DO - 10.1021/jp900266k

M3 - Article

C2 - 20161175

AN - SCOPUS:65249185742

SN - 1932-7447

VL - 113

SP - 5891

EP - 5894

JO - Journal of Physical Chemistry C

JF - Journal of Physical Chemistry C

IS - 15

ER -

Detection and identification of bioanalytes with high resolution LSPR spectroscopy and MALDI mass spectrometry

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this