Detection and identification of bioanalytes with high resolution LSPR spectroscopy and MALDI mass spectrometry

Jeffrey N. Anker, W. Paige Hall, Mary P. Lambert, Pauline T. Velasco, Milan Mrksich, William L. Klein, Richard P. Van Duyne

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

High resolution localized surface plasmon resonance (HR-LSPR) sensors were combined with matrix assisted laser desorption ionization mass spectrometry (MALDI-MS) for the first time. LSPR sensors provide real-time label-free detection of molecular adsorption. Subsequent MALDI-MS analysis enables identification of the adsorbed molecules. This synergistic LSPR-MS approach was applied to the detection and identification of amyloid beta oligomers which play an important role in the molecular pathogenesis of Alzheimer's Disease.

Original languageEnglish (US)
Pages (from-to)5891-5894
Number of pages4
JournalJournal of Physical Chemistry C
Volume113
Issue number15
DOIs
StatePublished - Apr 16 2009

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Energy(all)
  • Physical and Theoretical Chemistry
  • Surfaces, Coatings and Films

Fingerprint Dive into the research topics of 'Detection and identification of bioanalytes with high resolution LSPR spectroscopy and MALDI mass spectrometry'. Together they form a unique fingerprint.

Cite this