Detection and management of drug-resistant tuberculosis in HIV-infected patients in lower-income countries

M. Ballif*, V. Nhandu, R. Wood, J. C. Dusingize, E. J. Carter, C. P. Cortes, C. C. McGowan, L. Diero, C. Graber, L. Renner, D. Hawerlander, S. Kiertiburanakul, Q. T. Du, T. R. Sterling, M. Egger, L. Fenner, S. Ajayi, K. Anastos, M. Ballif, J. Bashi & 380 others W. Bishai, A. Boulle, P. Braitstein, G. Carriquiry, J. E. Carter, P. Cegielski, C. Chimbetete, J. Conrad, C. P. Cortes, M. A. Davies, L. Diero, S. Duda, N. Durier, J. C. Dusingize, M. Egger, T. F. Eboua, L. Fenner, A. Gasser, E. Geng, L. Hardwicke, C. Hoffmann, R. Huebner, N. Kancheya, S. Kiertiburanakul, P. Kim, D. Lameck, V. Leroy, C. Lewden, M. L. Lindegren, A. Mandalakas, M. Maskew, R. McKaig, L. Mofenson, M. Mpoudi-Etame, B. Okwara, S. Phiri, W. Prasitsuebsai, A. Petit, H. Prozesky, S. E. Reid, L. Renner, G. Reubenson, A. Sohn, T. R. Sterling, Q. Vo, D. Walker, F. Wehbe, C. Wejse, W. Wester, C. Williams, R. Wood, K. Wools-Kaloustian, Z. Yao, E. Yunihastuti, F. J. Zhang, H. X. Zhao, N. Han, T. P. Merati, D. N. Wirawan, F. Yuliana, R. Ditangco, E. Uy, R. Bantique, P. Phanuphak, K. Ruxrungtham, A. Avihingsanon, T. Mengthaisong, S. Kiertiburanakul, S. Sungkanuparph, N. Sanmeema, R. Chaiwarith, T. Sirisanthana, W. Kotarathititum, T. T. Pham, D. D. Cuong, H. L. Ha, V. K. Nguyen, V. H. Bui, T. T. Cao, A. H. Sohn, N. Durier, B. Petersen, D. A. Cooper, M. G. Law, A. Jiamsakul, D. C. Boettiger, D. K. Wati, L. P P Atmikasari, I. Y. Malino, R. Nallusamy, K. C. Chan, P. Lumbiganon, P. Kosalaraksa, P. Tharnprisan, T. Udomphanit, K. Chokephaibulkit, K. Lapphra, W. Phongsamart, O. Wittawatmongkol, K. T K Dung, N. V. Lam, P. N. An, N. T. Loan, H. K. Truong, T. Q. Du, N. H. Chau, C. V. Do, M. T. Ha, A. H. Sohn, N. Durier, P. Nipathakosol, D. A. Cooper, M. G. Law, A. Kariminia, J. C. Dusingize, E. Mutimura, A. Gitembagara, K. Anastos, J. Tatwangire, I. Izabelle, T. Niyongabo, C. Twizere, E. Baramperanye, A. Edmonds, M. Yotebieng, I. Azinyue, L. Ayangma, C. Yiannoutsos, S. Ayaya, E. A. Bukusi, J. Lewis-Kulzer, G. Somi, R. Lyamuya, K. Ngonyani, J. Ssali, H. Ssemuwemba, B. B. Mwebesa, A. Kambugu, S. Hermans, F. Nalugoda, K. Jjingo, C. Chimbetete, D. Dickinsonn, B. Eley, C. Fritz, D. Garone, J. Giddy, C. Hoffmann, P. MacPhail, H. Moultrie, J. Ndirangu, S. Pestilli, S. Phiri, H. Prozesky, H. Rabie, J. Stringer, K. Technau, R. Wood, M. Egger, C. Graber, F. Kaeser, O. Keiser, A. Boulle, M. Cornell, M. A. Davies, N. Maxwell, D. M. Zannou, C. Ahouada, J. Akakpo, C. Ahomadegbé, J. Bashi, A. Gougounon-Houéto, A. Azon-Kouanou, F. Houngbé, J. Sehonou, S. Koumakpaï, F. Alihonou, M. D'Almeida, I. Hodonou, G. Hounhoui, G. Sagbo, L. Tossa-Bagnan, H. Adjide, J. Drabo, R. Bognounou, A. Dienderé, E. Traore, L. Zoungrana, B. Zerbo, A. B. Sawadogo, J. Zoungrana, A. Héma, I. Soré, G. Bado, A. Tapsoba, D. Yé, F. Kouéta, S. Ouedraogo, R. Ouédraogo, W. Hiembo, M. Gansonré, E. Messou, J. C. Gnokoro, M. Koné, G. M. Kouakou, C. A. Bosse, K. Brou, A. I. Assi, H. Chenal, D. Hawerlander, F. Soppi, A. Minga, Y. Abo, J. M. Yoboue, S. P. Eholié, M. D N Amego, V. Andavi, Z. Diallo, F. Ello, A. K. Tanon, S. O. Koule, K. C. Anzan, C. Guehi, E. A. Aka, K. L. Issouf, J. C. Kouakou, M. S. N'Gbeche, T. Pety, D. Avit-Edi, K. Kouakou, M. Moh, V. A. Yao, M. A. Folquet, M. E. Dainguy, C. Kouakou, V. T. Méa-Assande, G. Oka-Berete, N. Zobo, P. Acquah, M. B. Kokora, T. F. Eboua, M. Timité-Konan, L. Diecket Ahoussou, J. K. Assouan, M. F. Sami, S. Kouadio, L. Renner, B. Goka, J. Welbeck, A. Sackey, S. N. Owiafe, Z. J. Da Silva, J. Paulo, A. Rodrigues, D. Da Silva, C. Medina, I. Oliviera-Souto, L. Østergaard, A. Laursen, M. Sodemann, P. Aaby, A. Fomsgaard, C. Erikstrup, J. Eugen-Olsen, M. Y. Maïga, F. F. Diakité, A. Kalle, D. Katile, H. A. Traore, D. Minta, T. Cissé, M. Dembelé, M. Doumbia, M. Fomba, A. S. Kaya, A. M. Traoré, H. Traoré, A. A. Toure, F. Dicko, M. Sylla, A. Berthé, H. C. Traoré, A. Koïta, N. Koné, C. N'Diaye, S. T. Coulibaly, M. Traoré, N. Traoré, M. Charurat, S. Ajayi, G. Alim, S. Dapiap, F. Igbinoba, O. Benson, C. Adebamowo, J. James, Obaseki, P. Osakede, J. Olasode, M. Seydi, P. S. Sow, B. Diop, N. M. Manga, J. M. Tine, C. C. Bassabi, H. S. Sy, A. Ba, A. Diagne, H. Dior, M. Faye, R. D. Gueye, A. D. Mbaye, A. Patassi, A. Kotosso, B. G. Kariyare, G. Gbadamassi, A. Komi, K. E. Mensah-Zukong, P. Pakpame, A. Koko Lawson-Evi, Y. Atakouma, E. Takassi, A. Djeha, A. Ephoévi-gah, S. El-Hadj Djibril, F. Dabis, E. Bissagnene, E. Arrivé, P. Coffie, D. Ekouevi, A. Jaquet, V. Leroy, C. Lewden, A. J. Sasco, D. Amani, J. C. Azani, E. Balestre, S. Bessekon, F. Bohossou, C. Gilbert, S. Karcher, J. M. Gonsan, J. Le Carrou, S. Lenaud, C. Nchot, K. Malateste, A. R. Yao, B. Siloué, G. Clouet, M. Dosso, A. Doring, A. Kouakou, E. Rabourdin, J. Rivenc, X. Anglaret, B. Ba, J. B. Essanin, A. Ciaranello, S. Datté, S. Desmonde, J. S. Elvis Diby, G. S. Gottlieb, A. G. Horo, S. N. Kangah, D. Malvy, D. Meless, A. Mounkaila-Harouna, C. Ndondoki, C. Shiboski, B. Tchounga, R. Thiébaut, G. Wandeler, C. McGowan, P. Cahn, E. Gotuzzo, M. Wolff, B. Grinsztejn, J. Pape, D. Padgett, J. S. Madero

*Corresponding author for this work

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

SETTING: Drug resistance threatens tuberculosis (TB) control, particularly among human immunodeficiency virus (HIV) infected persons. OBJECTIVE: To describe practices in the prevention and management of drug-resistant TB under antiretroviral therapy (ART) programs in lower-income countries. DESIGN: We used online questionnaires to collect program-level data on 47 ART programs in Southern Africa (n =14), East Africa (n = 8), West Africa (n = 7), Central Africa (n = 5), Latin America (n = 7) and the Asia-Pacific (n=6 programs) in 2012. Patient-level data were collected on 1002 adult TB patients seen at 40 of the participating ART programs. RESULTS: Phenotypic drug susceptibility testing (DST) was available in 36 (77%) ART programs, but was only used for 22% of all TB patients. Molecular DST was available in 33 (70%) programs and was used in 23% of all TB patients. Twenty ART programs (43%) provided directly observed therapy (DOT) during the entire course of treatment, 16 (34%) during the intensive phase only, and 11 (23%) did not follow DOT. Fourteen (30%) ART programs reported no access to second-line anti-tuberculosis regimens; 18 (38%) reported TB drug shortages. CONCLUSIONS: Capacity to diagnose and treat drugresistant TB was limited across ART programs in lowerincome countries. DOT was not always implemented and drug supplies were regularly interrupted, which may contribute to the global emergence of drug resistance.

Original languageEnglish (US)
Pages (from-to)1327-1336
Number of pages10
JournalInternational Journal of Tuberculosis and Lung Disease
Volume18
Issue number11
DOIs
StatePublished - Nov 1 2014

Fingerprint

Multidrug-Resistant Tuberculosis
HIV
Tuberculosis
Directly Observed Therapy
Therapeutics
Drug Resistance
Pharmaceutical Preparations
Central Africa
Southern Africa
Eastern Africa
Western Africa
Latin America

Keywords

  • ART programs
  • Africa
  • Asia
  • Latin America
  • MDR-TB

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases

Cite this

Ballif, M. ; Nhandu, V. ; Wood, R. ; Dusingize, J. C. ; Carter, E. J. ; Cortes, C. P. ; McGowan, C. C. ; Diero, L. ; Graber, C. ; Renner, L. ; Hawerlander, D. ; Kiertiburanakul, S. ; Du, Q. T. ; Sterling, T. R. ; Egger, M. ; Fenner, L. ; Ajayi, S. ; Anastos, K. ; Ballif, M. ; Bashi, J. ; Bishai, W. ; Boulle, A. ; Braitstein, P. ; Carriquiry, G. ; Carter, J. E. ; Cegielski, P. ; Chimbetete, C. ; Conrad, J. ; Cortes, C. P. ; Davies, M. A. ; Diero, L. ; Duda, S. ; Durier, N. ; Dusingize, J. C. ; Egger, M. ; Eboua, T. F. ; Fenner, L. ; Gasser, A. ; Geng, E. ; Hardwicke, L. ; Hoffmann, C. ; Huebner, R. ; Kancheya, N. ; Kiertiburanakul, S. ; Kim, P. ; Lameck, D. ; Leroy, V. ; Lewden, C. ; Lindegren, M. L. ; Mandalakas, A. ; Maskew, M. ; McKaig, R. ; Mofenson, L. ; Mpoudi-Etame, M. ; Okwara, B. ; Phiri, S. ; Prasitsuebsai, W. ; Petit, A. ; Prozesky, H. ; Reid, S. E. ; Renner, L. ; Reubenson, G. ; Sohn, A. ; Sterling, T. R. ; Vo, Q. ; Walker, D. ; Wehbe, F. ; Wejse, C. ; Wester, W. ; Williams, C. ; Wood, R. ; Wools-Kaloustian, K. ; Yao, Z. ; Yunihastuti, E. ; Zhang, F. J. ; Zhao, H. X. ; Han, N. ; Merati, T. P. ; Wirawan, D. N. ; Yuliana, F. ; Ditangco, R. ; Uy, E. ; Bantique, R. ; Phanuphak, P. ; Ruxrungtham, K. ; Avihingsanon, A. ; Mengthaisong, T. ; Kiertiburanakul, S. ; Sungkanuparph, S. ; Sanmeema, N. ; Chaiwarith, R. ; Sirisanthana, T. ; Kotarathititum, W. ; Pham, T. T. ; Cuong, D. D. ; Ha, H. L. ; Nguyen, V. K. ; Bui, V. H. ; Cao, T. T. ; Sohn, A. H. ; Durier, N. ; Petersen, B. ; Cooper, D. A. ; Law, M. G. ; Jiamsakul, A. ; Boettiger, D. C. ; Wati, D. K. ; Atmikasari, L. P P ; Malino, I. Y. ; Nallusamy, R. ; Chan, K. C. ; Lumbiganon, P. ; Kosalaraksa, P. ; Tharnprisan, P. ; Udomphanit, T. ; Chokephaibulkit, K. ; Lapphra, K. ; Phongsamart, W. ; Wittawatmongkol, O. ; Dung, K. T K ; Lam, N. V. ; An, P. N. ; Loan, N. T. ; Truong, H. K. ; Du, T. Q. ; Chau, N. H. ; Do, C. V. ; Ha, M. T. ; Sohn, A. H. ; Durier, N. ; Nipathakosol, P. ; Cooper, D. A. ; Law, M. G. ; Kariminia, A. ; Dusingize, J. C. ; Mutimura, E. ; Gitembagara, A. ; Anastos, K. ; Tatwangire, J. ; Izabelle, I. ; Niyongabo, T. ; Twizere, C. ; Baramperanye, E. ; Edmonds, A. ; Yotebieng, M. ; Azinyue, I. ; Ayangma, L. ; Yiannoutsos, C. ; Ayaya, S. ; Bukusi, E. A. ; Lewis-Kulzer, J. ; Somi, G. ; Lyamuya, R. ; Ngonyani, K. ; Ssali, J. ; Ssemuwemba, H. ; Mwebesa, B. B. ; Kambugu, A. ; Hermans, S. ; Nalugoda, F. ; Jjingo, K. ; Chimbetete, C. ; Dickinsonn, D. ; Eley, B. ; Fritz, C. ; Garone, D. ; Giddy, J. ; Hoffmann, C. ; MacPhail, P. ; Moultrie, H. ; Ndirangu, J. ; Pestilli, S. ; Phiri, S. ; Prozesky, H. ; Rabie, H. ; Stringer, J. ; Technau, K. ; Wood, R. ; Egger, M. ; Graber, C. ; Kaeser, F. ; Keiser, O. ; Boulle, A. ; Cornell, M. ; Davies, M. A. ; Maxwell, N. ; Zannou, D. M. ; Ahouada, C. ; Akakpo, J. ; Ahomadegbé, C. ; Bashi, J. ; Gougounon-Houéto, A. ; Azon-Kouanou, A. ; Houngbé, F. ; Sehonou, J. ; Koumakpaï, S. ; Alihonou, F. ; D'Almeida, M. ; Hodonou, I. ; Hounhoui, G. ; Sagbo, G. ; Tossa-Bagnan, L. ; Adjide, H. ; Drabo, J. ; Bognounou, R. ; Dienderé, A. ; Traore, E. ; Zoungrana, L. ; Zerbo, B. ; Sawadogo, A. B. ; Zoungrana, J. ; Héma, A. ; Soré, I. ; Bado, G. ; Tapsoba, A. ; Yé, D. ; Kouéta, F. ; Ouedraogo, S. ; Ouédraogo, R. ; Hiembo, W. ; Gansonré, M. ; Messou, E. ; Gnokoro, J. C. ; Koné, M. ; Kouakou, G. M. ; Bosse, C. A. ; Brou, K. ; Assi, A. I. ; Chenal, H. ; Hawerlander, D. ; Soppi, F. ; Minga, A. ; Abo, Y. ; Yoboue, J. M. ; Eholié, S. P. ; Amego, M. D N ; Andavi, V. ; Diallo, Z. ; Ello, F. ; Tanon, A. K. ; Koule, S. O. ; Anzan, K. C. ; Guehi, C. ; Aka, E. A. ; Issouf, K. L. ; Kouakou, J. C. ; N'Gbeche, M. S. ; Pety, T. ; Avit-Edi, D. ; Kouakou, K. ; Moh, M. ; Yao, V. A. ; Folquet, M. A. ; Dainguy, M. E. ; Kouakou, C. ; Méa-Assande, V. T. ; Oka-Berete, G. ; Zobo, N. ; Acquah, P. ; Kokora, M. B. ; Eboua, T. F. ; Timité-Konan, M. ; Diecket Ahoussou, L. ; Assouan, J. K. ; Sami, M. F. ; Kouadio, S. ; Renner, L. ; Goka, B. ; Welbeck, J. ; Sackey, A. ; Owiafe, S. N. ; Da Silva, Z. J. ; Paulo, J. ; Rodrigues, A. ; Da Silva, D. ; Medina, C. ; Oliviera-Souto, I. ; Østergaard, L. ; Laursen, A. ; Sodemann, M. ; Aaby, P. ; Fomsgaard, A. ; Erikstrup, C. ; Eugen-Olsen, J. ; Maïga, M. Y. ; Diakité, F. F. ; Kalle, A. ; Katile, D. ; Traore, H. A. ; Minta, D. ; Cissé, T. ; Dembelé, M. ; Doumbia, M. ; Fomba, M. ; Kaya, A. S. ; Traoré, A. M. ; Traoré, H. ; Toure, A. A. ; Dicko, F. ; Sylla, M. ; Berthé, A. ; Traoré, H. C. ; Koïta, A. ; Koné, N. ; N'Diaye, C. ; Coulibaly, S. T. ; Traoré, M. ; Traoré, N. ; Charurat, M. ; Ajayi, S. ; Alim, G. ; Dapiap, S. ; Igbinoba, F. ; Benson, O. ; Adebamowo, C. ; James, J. ; Obaseki ; Osakede, P. ; Olasode, J. ; Seydi, M. ; Sow, P. S. ; Diop, B. ; Manga, N. M. ; Tine, J. M. ; Bassabi, C. C. ; Sy, H. S. ; Ba, A. ; Diagne, A. ; Dior, H. ; Faye, M. ; Gueye, R. D. ; Mbaye, A. D. ; Patassi, A. ; Kotosso, A. ; Kariyare, B. G. ; Gbadamassi, G. ; Komi, A. ; Mensah-Zukong, K. E. ; Pakpame, P. ; Koko Lawson-Evi, A. ; Atakouma, Y. ; Takassi, E. ; Djeha, A. ; Ephoévi-gah, A. ; El-Hadj Djibril, S. ; Dabis, F. ; Bissagnene, E. ; Arrivé, E. ; Coffie, P. ; Ekouevi, D. ; Jaquet, A. ; Leroy, V. ; Lewden, C. ; Sasco, A. J. ; Amani, D. ; Azani, J. C. ; Balestre, E. ; Bessekon, S. ; Bohossou, F. ; Gilbert, C. ; Karcher, S. ; Gonsan, J. M. ; Le Carrou, J. ; Lenaud, S. ; Nchot, C. ; Malateste, K. ; Yao, A. R. ; Siloué, B. ; Clouet, G. ; Dosso, M. ; Doring, A. ; Kouakou, A. ; Rabourdin, E. ; Rivenc, J. ; Anglaret, X. ; Ba, B. ; Essanin, J. B. ; Ciaranello, A. ; Datté, S. ; Desmonde, S. ; Elvis Diby, J. S. ; Gottlieb, G. S. ; Horo, A. G. ; Kangah, S. N. ; Malvy, D. ; Meless, D. ; Mounkaila-Harouna, A. ; Ndondoki, C. ; Shiboski, C. ; Tchounga, B. ; Thiébaut, R. ; Wandeler, G. ; McGowan, C. ; Cahn, P. ; Gotuzzo, E. ; Wolff, M. ; Grinsztejn, B. ; Pape, J. ; Padgett, D. ; Madero, J. S. / Detection and management of drug-resistant tuberculosis in HIV-infected patients in lower-income countries. In: International Journal of Tuberculosis and Lung Disease. 2014 ; Vol. 18, No. 11. pp. 1327-1336.
@article{71ce6dda52254cc3865615418c81adc7,
title = "Detection and management of drug-resistant tuberculosis in HIV-infected patients in lower-income countries",
abstract = "SETTING: Drug resistance threatens tuberculosis (TB) control, particularly among human immunodeficiency virus (HIV) infected persons. OBJECTIVE: To describe practices in the prevention and management of drug-resistant TB under antiretroviral therapy (ART) programs in lower-income countries. DESIGN: We used online questionnaires to collect program-level data on 47 ART programs in Southern Africa (n =14), East Africa (n = 8), West Africa (n = 7), Central Africa (n = 5), Latin America (n = 7) and the Asia-Pacific (n=6 programs) in 2012. Patient-level data were collected on 1002 adult TB patients seen at 40 of the participating ART programs. RESULTS: Phenotypic drug susceptibility testing (DST) was available in 36 (77{\%}) ART programs, but was only used for 22{\%} of all TB patients. Molecular DST was available in 33 (70{\%}) programs and was used in 23{\%} of all TB patients. Twenty ART programs (43{\%}) provided directly observed therapy (DOT) during the entire course of treatment, 16 (34{\%}) during the intensive phase only, and 11 (23{\%}) did not follow DOT. Fourteen (30{\%}) ART programs reported no access to second-line anti-tuberculosis regimens; 18 (38{\%}) reported TB drug shortages. CONCLUSIONS: Capacity to diagnose and treat drugresistant TB was limited across ART programs in lowerincome countries. DOT was not always implemented and drug supplies were regularly interrupted, which may contribute to the global emergence of drug resistance.",
keywords = "ART programs, Africa, Asia, Latin America, MDR-TB",
author = "M. Ballif and V. Nhandu and R. Wood and Dusingize, {J. C.} and Carter, {E. J.} and Cortes, {C. P.} and McGowan, {C. C.} and L. Diero and C. Graber and L. Renner and D. Hawerlander and S. Kiertiburanakul and Du, {Q. T.} and Sterling, {T. R.} and M. Egger and L. Fenner and S. Ajayi and K. Anastos and M. Ballif and J. Bashi and W. Bishai and A. Boulle and P. Braitstein and G. Carriquiry and Carter, {J. E.} and P. Cegielski and C. Chimbetete and J. Conrad and Cortes, {C. P.} and Davies, {M. A.} and L. Diero and S. Duda and N. Durier and Dusingize, {J. C.} and M. Egger and Eboua, {T. F.} and L. Fenner and A. Gasser and E. Geng and L. Hardwicke and C. Hoffmann and R. Huebner and N. Kancheya and S. Kiertiburanakul and P. Kim and D. Lameck and V. Leroy and C. Lewden and Lindegren, {M. L.} and A. Mandalakas and M. Maskew and R. McKaig and L. Mofenson and M. Mpoudi-Etame and B. Okwara and S. Phiri and W. Prasitsuebsai and A. Petit and H. Prozesky and Reid, {S. E.} and L. Renner and G. Reubenson and A. Sohn and Sterling, {T. R.} and Q. Vo and D. Walker and F. Wehbe and C. Wejse and W. Wester and C. Williams and R. Wood and K. Wools-Kaloustian and Z. Yao and E. Yunihastuti and Zhang, {F. J.} and Zhao, {H. X.} and N. Han and Merati, {T. P.} and Wirawan, {D. N.} and F. Yuliana and R. Ditangco and E. Uy and R. Bantique and P. Phanuphak and K. Ruxrungtham and A. Avihingsanon and T. Mengthaisong and S. Kiertiburanakul and S. Sungkanuparph and N. Sanmeema and R. Chaiwarith and T. Sirisanthana and W. Kotarathititum and Pham, {T. T.} and Cuong, {D. D.} and Ha, {H. L.} and Nguyen, {V. K.} and Bui, {V. H.} and Cao, {T. T.} and Sohn, {A. H.} and N. Durier and B. Petersen and Cooper, {D. A.} and Law, {M. G.} and A. Jiamsakul and Boettiger, {D. C.} and Wati, {D. K.} and Atmikasari, {L. P P} and Malino, {I. Y.} and R. Nallusamy and Chan, {K. C.} and P. Lumbiganon and P. Kosalaraksa and P. Tharnprisan and T. Udomphanit and K. Chokephaibulkit and K. Lapphra and W. Phongsamart and O. Wittawatmongkol and Dung, {K. T K} and Lam, {N. V.} and An, {P. N.} and Loan, {N. T.} and Truong, {H. K.} and Du, {T. Q.} and Chau, {N. H.} and Do, {C. V.} and Ha, {M. T.} and Sohn, {A. H.} and N. Durier and P. Nipathakosol and Cooper, {D. A.} and Law, {M. G.} and A. Kariminia and Dusingize, {J. C.} and E. Mutimura and A. Gitembagara and K. Anastos and J. Tatwangire and I. Izabelle and T. Niyongabo and C. Twizere and E. Baramperanye and A. Edmonds and M. Yotebieng and I. Azinyue and L. Ayangma and C. Yiannoutsos and S. Ayaya and Bukusi, {E. A.} and J. Lewis-Kulzer and G. Somi and R. Lyamuya and K. Ngonyani and J. Ssali and H. Ssemuwemba and Mwebesa, {B. B.} and A. Kambugu and S. Hermans and F. Nalugoda and K. Jjingo and C. Chimbetete and D. Dickinsonn and B. Eley and C. Fritz and D. Garone and J. Giddy and C. Hoffmann and P. MacPhail and H. Moultrie and J. Ndirangu and S. Pestilli and S. Phiri and H. Prozesky and H. Rabie and J. Stringer and K. Technau and R. Wood and M. Egger and C. Graber and F. Kaeser and O. Keiser and A. Boulle and M. Cornell and Davies, {M. A.} and N. Maxwell and Zannou, {D. M.} and C. Ahouada and J. Akakpo and C. Ahomadegb{\'e} and J. Bashi and A. Gougounon-Hou{\'e}to and A. Azon-Kouanou and F. Houngb{\'e} and J. Sehonou and S. Koumakpa{\"i} and F. Alihonou and M. D'Almeida and I. Hodonou and G. Hounhoui and G. Sagbo and L. Tossa-Bagnan and H. Adjide and J. Drabo and R. Bognounou and A. Diender{\'e} and E. Traore and L. Zoungrana and B. Zerbo and Sawadogo, {A. B.} and J. Zoungrana and A. H{\'e}ma and I. Sor{\'e} and G. Bado and A. Tapsoba and D. Y{\'e} and F. Kou{\'e}ta and S. Ouedraogo and R. Ou{\'e}draogo and W. Hiembo and M. Gansonr{\'e} and E. Messou and Gnokoro, {J. C.} and M. Kon{\'e} and Kouakou, {G. M.} and Bosse, {C. A.} and K. Brou and Assi, {A. I.} and H. Chenal and D. Hawerlander and F. Soppi and A. Minga and Y. Abo and Yoboue, {J. M.} and Eholi{\'e}, {S. P.} and Amego, {M. D N} and V. Andavi and Z. Diallo and F. Ello and Tanon, {A. K.} and Koule, {S. O.} and Anzan, {K. C.} and C. Guehi and Aka, {E. A.} and Issouf, {K. L.} and Kouakou, {J. C.} and N'Gbeche, {M. S.} and T. Pety and D. Avit-Edi and K. Kouakou and M. Moh and Yao, {V. A.} and Folquet, {M. A.} and Dainguy, {M. E.} and C. Kouakou and M{\'e}a-Assande, {V. T.} and G. Oka-Berete and N. Zobo and P. Acquah and Kokora, {M. B.} and Eboua, {T. F.} and M. Timit{\'e}-Konan and {Diecket Ahoussou}, L. and Assouan, {J. K.} and Sami, {M. F.} and S. Kouadio and L. Renner and B. Goka and J. Welbeck and A. Sackey and Owiafe, {S. N.} and {Da Silva}, {Z. J.} and J. Paulo and A. Rodrigues and {Da Silva}, D. and C. Medina and I. Oliviera-Souto and L. {\O}stergaard and A. Laursen and M. Sodemann and P. Aaby and A. Fomsgaard and C. Erikstrup and J. Eugen-Olsen and Ma{\"i}ga, {M. Y.} and Diakit{\'e}, {F. F.} and A. Kalle and D. Katile and Traore, {H. A.} and D. Minta and T. Ciss{\'e} and M. Dembel{\'e} and M. Doumbia and M. Fomba and Kaya, {A. S.} and Traor{\'e}, {A. M.} and H. Traor{\'e} and Toure, {A. A.} and F. Dicko and M. Sylla and A. Berth{\'e} and Traor{\'e}, {H. C.} and A. Ko{\"i}ta and N. Kon{\'e} and C. N'Diaye and Coulibaly, {S. T.} and M. Traor{\'e} and N. Traor{\'e} and M. Charurat and S. Ajayi and G. Alim and S. Dapiap and F. Igbinoba and O. Benson and C. Adebamowo and J. James and Obaseki and P. Osakede and J. Olasode and M. Seydi and Sow, {P. S.} and B. Diop and Manga, {N. M.} and Tine, {J. M.} and Bassabi, {C. C.} and Sy, {H. S.} and A. Ba and A. Diagne and H. Dior and M. Faye and Gueye, {R. D.} and Mbaye, {A. D.} and A. Patassi and A. Kotosso and Kariyare, {B. G.} and G. Gbadamassi and A. Komi and Mensah-Zukong, {K. E.} and P. Pakpame and {Koko Lawson-Evi}, A. and Y. Atakouma and E. Takassi and A. Djeha and A. Epho{\'e}vi-gah and {El-Hadj Djibril}, S. and F. Dabis and E. Bissagnene and E. Arriv{\'e} and P. Coffie and D. Ekouevi and A. Jaquet and V. Leroy and C. Lewden and Sasco, {A. J.} and D. Amani and Azani, {J. C.} and E. Balestre and S. Bessekon and F. Bohossou and C. Gilbert and S. Karcher and Gonsan, {J. M.} and {Le Carrou}, J. and S. Lenaud and C. Nchot and K. Malateste and Yao, {A. R.} and B. Silou{\'e} and G. Clouet and M. Dosso and A. Doring and A. Kouakou and E. Rabourdin and J. Rivenc and X. Anglaret and B. Ba and Essanin, {J. B.} and A. Ciaranello and S. Datt{\'e} and S. Desmonde and {Elvis Diby}, {J. S.} and Gottlieb, {G. S.} and Horo, {A. G.} and Kangah, {S. N.} and D. Malvy and D. Meless and A. Mounkaila-Harouna and C. Ndondoki and C. Shiboski and B. Tchounga and R. Thi{\'e}baut and G. Wandeler and C. McGowan and P. Cahn and E. Gotuzzo and M. Wolff and B. Grinsztejn and J. Pape and D. Padgett and Madero, {J. S.}",
year = "2014",
month = "11",
day = "1",
doi = "10.5588/ijtld.14.0106",
language = "English (US)",
volume = "18",
pages = "1327--1336",
journal = "International Journal of Tuberculosis and Lung Disease",
issn = "1027-3719",
publisher = "International Union against Tubercul. and Lung Dis.",
number = "11",

}

Ballif, M, Nhandu, V, Wood, R, Dusingize, JC, Carter, EJ, Cortes, CP, McGowan, CC, Diero, L, Graber, C, Renner, L, Hawerlander, D, Kiertiburanakul, S, Du, QT, Sterling, TR, Egger, M, Fenner, L, Ajayi, S, Anastos, K, Ballif, M, Bashi, J, Bishai, W, Boulle, A, Braitstein, P, Carriquiry, G, Carter, JE, Cegielski, P, Chimbetete, C, Conrad, J, Cortes, CP, Davies, MA, Diero, L, Duda, S, Durier, N, Dusingize, JC, Egger, M, Eboua, TF, Fenner, L, Gasser, A, Geng, E, Hardwicke, L, Hoffmann, C, Huebner, R, Kancheya, N, Kiertiburanakul, S, Kim, P, Lameck, D, Leroy, V, Lewden, C, Lindegren, ML, Mandalakas, A, Maskew, M, McKaig, R, Mofenson, L, Mpoudi-Etame, M, Okwara, B, Phiri, S, Prasitsuebsai, W, Petit, A, Prozesky, H, Reid, SE, Renner, L, Reubenson, G, Sohn, A, Sterling, TR, Vo, Q, Walker, D, Wehbe, F, Wejse, C, Wester, W, Williams, C, Wood, R, Wools-Kaloustian, K, Yao, Z, Yunihastuti, E, Zhang, FJ, Zhao, HX, Han, N, Merati, TP, Wirawan, DN, Yuliana, F, Ditangco, R, Uy, E, Bantique, R, Phanuphak, P, Ruxrungtham, K, Avihingsanon, A, Mengthaisong, T, Kiertiburanakul, S, Sungkanuparph, S, Sanmeema, N, Chaiwarith, R, Sirisanthana, T, Kotarathititum, W, Pham, TT, Cuong, DD, Ha, HL, Nguyen, VK, Bui, VH, Cao, TT, Sohn, AH, Durier, N, Petersen, B, Cooper, DA, Law, MG, Jiamsakul, A, Boettiger, DC, Wati, DK, Atmikasari, LPP, Malino, IY, Nallusamy, R, Chan, KC, Lumbiganon, P, Kosalaraksa, P, Tharnprisan, P, Udomphanit, T, Chokephaibulkit, K, Lapphra, K, Phongsamart, W, Wittawatmongkol, O, Dung, KTK, Lam, NV, An, PN, Loan, NT, Truong, HK, Du, TQ, Chau, NH, Do, CV, Ha, MT, Sohn, AH, Durier, N, Nipathakosol, P, Cooper, DA, Law, MG, Kariminia, A, Dusingize, JC, Mutimura, E, Gitembagara, A, Anastos, K, Tatwangire, J, Izabelle, I, Niyongabo, T, Twizere, C, Baramperanye, E, Edmonds, A, Yotebieng, M, Azinyue, I, Ayangma, L, Yiannoutsos, C, Ayaya, S, Bukusi, EA, Lewis-Kulzer, J, Somi, G, Lyamuya, R, Ngonyani, K, Ssali, J, Ssemuwemba, H, Mwebesa, BB, Kambugu, A, Hermans, S, Nalugoda, F, Jjingo, K, Chimbetete, C, Dickinsonn, D, Eley, B, Fritz, C, Garone, D, Giddy, J, Hoffmann, C, MacPhail, P, Moultrie, H, Ndirangu, J, Pestilli, S, Phiri, S, Prozesky, H, Rabie, H, Stringer, J, Technau, K, Wood, R, Egger, M, Graber, C, Kaeser, F, Keiser, O, Boulle, A, Cornell, M, Davies, MA, Maxwell, N, Zannou, DM, Ahouada, C, Akakpo, J, Ahomadegbé, C, Bashi, J, Gougounon-Houéto, A, Azon-Kouanou, A, Houngbé, F, Sehonou, J, Koumakpaï, S, Alihonou, F, D'Almeida, M, Hodonou, I, Hounhoui, G, Sagbo, G, Tossa-Bagnan, L, Adjide, H, Drabo, J, Bognounou, R, Dienderé, A, Traore, E, Zoungrana, L, Zerbo, B, Sawadogo, AB, Zoungrana, J, Héma, A, Soré, I, Bado, G, Tapsoba, A, Yé, D, Kouéta, F, Ouedraogo, S, Ouédraogo, R, Hiembo, W, Gansonré, M, Messou, E, Gnokoro, JC, Koné, M, Kouakou, GM, Bosse, CA, Brou, K, Assi, AI, Chenal, H, Hawerlander, D, Soppi, F, Minga, A, Abo, Y, Yoboue, JM, Eholié, SP, Amego, MDN, Andavi, V, Diallo, Z, Ello, F, Tanon, AK, Koule, SO, Anzan, KC, Guehi, C, Aka, EA, Issouf, KL, Kouakou, JC, N'Gbeche, MS, Pety, T, Avit-Edi, D, Kouakou, K, Moh, M, Yao, VA, Folquet, MA, Dainguy, ME, Kouakou, C, Méa-Assande, VT, Oka-Berete, G, Zobo, N, Acquah, P, Kokora, MB, Eboua, TF, Timité-Konan, M, Diecket Ahoussou, L, Assouan, JK, Sami, MF, Kouadio, S, Renner, L, Goka, B, Welbeck, J, Sackey, A, Owiafe, SN, Da Silva, ZJ, Paulo, J, Rodrigues, A, Da Silva, D, Medina, C, Oliviera-Souto, I, Østergaard, L, Laursen, A, Sodemann, M, Aaby, P, Fomsgaard, A, Erikstrup, C, Eugen-Olsen, J, Maïga, MY, Diakité, FF, Kalle, A, Katile, D, Traore, HA, Minta, D, Cissé, T, Dembelé, M, Doumbia, M, Fomba, M, Kaya, AS, Traoré, AM, Traoré, H, Toure, AA, Dicko, F, Sylla, M, Berthé, A, Traoré, HC, Koïta, A, Koné, N, N'Diaye, C, Coulibaly, ST, Traoré, M, Traoré, N, Charurat, M, Ajayi, S, Alim, G, Dapiap, S, Igbinoba, F, Benson, O, Adebamowo, C, James, J, Obaseki, Osakede, P, Olasode, J, Seydi, M, Sow, PS, Diop, B, Manga, NM, Tine, JM, Bassabi, CC, Sy, HS, Ba, A, Diagne, A, Dior, H, Faye, M, Gueye, RD, Mbaye, AD, Patassi, A, Kotosso, A, Kariyare, BG, Gbadamassi, G, Komi, A, Mensah-Zukong, KE, Pakpame, P, Koko Lawson-Evi, A, Atakouma, Y, Takassi, E, Djeha, A, Ephoévi-gah, A, El-Hadj Djibril, S, Dabis, F, Bissagnene, E, Arrivé, E, Coffie, P, Ekouevi, D, Jaquet, A, Leroy, V, Lewden, C, Sasco, AJ, Amani, D, Azani, JC, Balestre, E, Bessekon, S, Bohossou, F, Gilbert, C, Karcher, S, Gonsan, JM, Le Carrou, J, Lenaud, S, Nchot, C, Malateste, K, Yao, AR, Siloué, B, Clouet, G, Dosso, M, Doring, A, Kouakou, A, Rabourdin, E, Rivenc, J, Anglaret, X, Ba, B, Essanin, JB, Ciaranello, A, Datté, S, Desmonde, S, Elvis Diby, JS, Gottlieb, GS, Horo, AG, Kangah, SN, Malvy, D, Meless, D, Mounkaila-Harouna, A, Ndondoki, C, Shiboski, C, Tchounga, B, Thiébaut, R, Wandeler, G, McGowan, C, Cahn, P, Gotuzzo, E, Wolff, M, Grinsztejn, B, Pape, J, Padgett, D & Madero, JS 2014, 'Detection and management of drug-resistant tuberculosis in HIV-infected patients in lower-income countries', International Journal of Tuberculosis and Lung Disease, vol. 18, no. 11, pp. 1327-1336. https://doi.org/10.5588/ijtld.14.0106

Detection and management of drug-resistant tuberculosis in HIV-infected patients in lower-income countries. / Ballif, M.; Nhandu, V.; Wood, R.; Dusingize, J. C.; Carter, E. J.; Cortes, C. P.; McGowan, C. C.; Diero, L.; Graber, C.; Renner, L.; Hawerlander, D.; Kiertiburanakul, S.; Du, Q. T.; Sterling, T. R.; Egger, M.; Fenner, L.; Ajayi, S.; Anastos, K.; Ballif, M.; Bashi, J.; Bishai, W.; Boulle, A.; Braitstein, P.; Carriquiry, G.; Carter, J. E.; Cegielski, P.; Chimbetete, C.; Conrad, J.; Cortes, C. P.; Davies, M. A.; Diero, L.; Duda, S.; Durier, N.; Dusingize, J. C.; Egger, M.; Eboua, T. F.; Fenner, L.; Gasser, A.; Geng, E.; Hardwicke, L.; Hoffmann, C.; Huebner, R.; Kancheya, N.; Kiertiburanakul, S.; Kim, P.; Lameck, D.; Leroy, V.; Lewden, C.; Lindegren, M. L.; Mandalakas, A.; Maskew, M.; McKaig, R.; Mofenson, L.; Mpoudi-Etame, M.; Okwara, B.; Phiri, S.; Prasitsuebsai, W.; Petit, A.; Prozesky, H.; Reid, S. E.; Renner, L.; Reubenson, G.; Sohn, A.; Sterling, T. R.; Vo, Q.; Walker, D.; Wehbe, F.; Wejse, C.; Wester, W.; Williams, C.; Wood, R.; Wools-Kaloustian, K.; Yao, Z.; Yunihastuti, E.; Zhang, F. J.; Zhao, H. X.; Han, N.; Merati, T. P.; Wirawan, D. N.; Yuliana, F.; Ditangco, R.; Uy, E.; Bantique, R.; Phanuphak, P.; Ruxrungtham, K.; Avihingsanon, A.; Mengthaisong, T.; Kiertiburanakul, S.; Sungkanuparph, S.; Sanmeema, N.; Chaiwarith, R.; Sirisanthana, T.; Kotarathititum, W.; Pham, T. T.; Cuong, D. D.; Ha, H. L.; Nguyen, V. K.; Bui, V. H.; Cao, T. T.; Sohn, A. H.; Durier, N.; Petersen, B.; Cooper, D. A.; Law, M. G.; Jiamsakul, A.; Boettiger, D. C.; Wati, D. K.; Atmikasari, L. P P; Malino, I. Y.; Nallusamy, R.; Chan, K. C.; Lumbiganon, P.; Kosalaraksa, P.; Tharnprisan, P.; Udomphanit, T.; Chokephaibulkit, K.; Lapphra, K.; Phongsamart, W.; Wittawatmongkol, O.; Dung, K. T K; Lam, N. V.; An, P. N.; Loan, N. T.; Truong, H. K.; Du, T. Q.; Chau, N. H.; Do, C. V.; Ha, M. T.; Sohn, A. H.; Durier, N.; Nipathakosol, P.; Cooper, D. A.; Law, M. G.; Kariminia, A.; Dusingize, J. C.; Mutimura, E.; Gitembagara, A.; Anastos, K.; Tatwangire, J.; Izabelle, I.; Niyongabo, T.; Twizere, C.; Baramperanye, E.; Edmonds, A.; Yotebieng, M.; Azinyue, I.; Ayangma, L.; Yiannoutsos, C.; Ayaya, S.; Bukusi, E. A.; Lewis-Kulzer, J.; Somi, G.; Lyamuya, R.; Ngonyani, K.; Ssali, J.; Ssemuwemba, H.; Mwebesa, B. B.; Kambugu, A.; Hermans, S.; Nalugoda, F.; Jjingo, K.; Chimbetete, C.; Dickinsonn, D.; Eley, B.; Fritz, C.; Garone, D.; Giddy, J.; Hoffmann, C.; MacPhail, P.; Moultrie, H.; Ndirangu, J.; Pestilli, S.; Phiri, S.; Prozesky, H.; Rabie, H.; Stringer, J.; Technau, K.; Wood, R.; Egger, M.; Graber, C.; Kaeser, F.; Keiser, O.; Boulle, A.; Cornell, M.; Davies, M. A.; Maxwell, N.; Zannou, D. M.; Ahouada, C.; Akakpo, J.; Ahomadegbé, C.; Bashi, J.; Gougounon-Houéto, A.; Azon-Kouanou, A.; Houngbé, F.; Sehonou, J.; Koumakpaï, S.; Alihonou, F.; D'Almeida, M.; Hodonou, I.; Hounhoui, G.; Sagbo, G.; Tossa-Bagnan, L.; Adjide, H.; Drabo, J.; Bognounou, R.; Dienderé, A.; Traore, E.; Zoungrana, L.; Zerbo, B.; Sawadogo, A. B.; Zoungrana, J.; Héma, A.; Soré, I.; Bado, G.; Tapsoba, A.; Yé, D.; Kouéta, F.; Ouedraogo, S.; Ouédraogo, R.; Hiembo, W.; Gansonré, M.; Messou, E.; Gnokoro, J. C.; Koné, M.; Kouakou, G. M.; Bosse, C. A.; Brou, K.; Assi, A. I.; Chenal, H.; Hawerlander, D.; Soppi, F.; Minga, A.; Abo, Y.; Yoboue, J. M.; Eholié, S. P.; Amego, M. D N; Andavi, V.; Diallo, Z.; Ello, F.; Tanon, A. K.; Koule, S. O.; Anzan, K. C.; Guehi, C.; Aka, E. A.; Issouf, K. L.; Kouakou, J. C.; N'Gbeche, M. S.; Pety, T.; Avit-Edi, D.; Kouakou, K.; Moh, M.; Yao, V. A.; Folquet, M. A.; Dainguy, M. E.; Kouakou, C.; Méa-Assande, V. T.; Oka-Berete, G.; Zobo, N.; Acquah, P.; Kokora, M. B.; Eboua, T. F.; Timité-Konan, M.; Diecket Ahoussou, L.; Assouan, J. K.; Sami, M. F.; Kouadio, S.; Renner, L.; Goka, B.; Welbeck, J.; Sackey, A.; Owiafe, S. N.; Da Silva, Z. J.; Paulo, J.; Rodrigues, A.; Da Silva, D.; Medina, C.; Oliviera-Souto, I.; Østergaard, L.; Laursen, A.; Sodemann, M.; Aaby, P.; Fomsgaard, A.; Erikstrup, C.; Eugen-Olsen, J.; Maïga, M. Y.; Diakité, F. F.; Kalle, A.; Katile, D.; Traore, H. A.; Minta, D.; Cissé, T.; Dembelé, M.; Doumbia, M.; Fomba, M.; Kaya, A. S.; Traoré, A. M.; Traoré, H.; Toure, A. A.; Dicko, F.; Sylla, M.; Berthé, A.; Traoré, H. C.; Koïta, A.; Koné, N.; N'Diaye, C.; Coulibaly, S. T.; Traoré, M.; Traoré, N.; Charurat, M.; Ajayi, S.; Alim, G.; Dapiap, S.; Igbinoba, F.; Benson, O.; Adebamowo, C.; James, J.; Obaseki; Osakede, P.; Olasode, J.; Seydi, M.; Sow, P. S.; Diop, B.; Manga, N. M.; Tine, J. M.; Bassabi, C. C.; Sy, H. S.; Ba, A.; Diagne, A.; Dior, H.; Faye, M.; Gueye, R. D.; Mbaye, A. D.; Patassi, A.; Kotosso, A.; Kariyare, B. G.; Gbadamassi, G.; Komi, A.; Mensah-Zukong, K. E.; Pakpame, P.; Koko Lawson-Evi, A.; Atakouma, Y.; Takassi, E.; Djeha, A.; Ephoévi-gah, A.; El-Hadj Djibril, S.; Dabis, F.; Bissagnene, E.; Arrivé, E.; Coffie, P.; Ekouevi, D.; Jaquet, A.; Leroy, V.; Lewden, C.; Sasco, A. J.; Amani, D.; Azani, J. C.; Balestre, E.; Bessekon, S.; Bohossou, F.; Gilbert, C.; Karcher, S.; Gonsan, J. M.; Le Carrou, J.; Lenaud, S.; Nchot, C.; Malateste, K.; Yao, A. R.; Siloué, B.; Clouet, G.; Dosso, M.; Doring, A.; Kouakou, A.; Rabourdin, E.; Rivenc, J.; Anglaret, X.; Ba, B.; Essanin, J. B.; Ciaranello, A.; Datté, S.; Desmonde, S.; Elvis Diby, J. S.; Gottlieb, G. S.; Horo, A. G.; Kangah, S. N.; Malvy, D.; Meless, D.; Mounkaila-Harouna, A.; Ndondoki, C.; Shiboski, C.; Tchounga, B.; Thiébaut, R.; Wandeler, G.; McGowan, C.; Cahn, P.; Gotuzzo, E.; Wolff, M.; Grinsztejn, B.; Pape, J.; Padgett, D.; Madero, J. S.

In: International Journal of Tuberculosis and Lung Disease, Vol. 18, No. 11, 01.11.2014, p. 1327-1336.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Detection and management of drug-resistant tuberculosis in HIV-infected patients in lower-income countries

AU - Ballif, M.

AU - Nhandu, V.

AU - Wood, R.

AU - Dusingize, J. C.

AU - Carter, E. J.

AU - Cortes, C. P.

AU - McGowan, C. C.

AU - Diero, L.

AU - Graber, C.

AU - Renner, L.

AU - Hawerlander, D.

AU - Kiertiburanakul, S.

AU - Du, Q. T.

AU - Sterling, T. R.

AU - Egger, M.

AU - Fenner, L.

AU - Ajayi, S.

AU - Anastos, K.

AU - Ballif, M.

AU - Bashi, J.

AU - Bishai, W.

AU - Boulle, A.

AU - Braitstein, P.

AU - Carriquiry, G.

AU - Carter, J. E.

AU - Cegielski, P.

AU - Chimbetete, C.

AU - Conrad, J.

AU - Cortes, C. P.

AU - Davies, M. A.

AU - Diero, L.

AU - Duda, S.

AU - Durier, N.

AU - Dusingize, J. C.

AU - Egger, M.

AU - Eboua, T. F.

AU - Fenner, L.

AU - Gasser, A.

AU - Geng, E.

AU - Hardwicke, L.

AU - Hoffmann, C.

AU - Huebner, R.

AU - Kancheya, N.

AU - Kiertiburanakul, S.

AU - Kim, P.

AU - Lameck, D.

AU - Leroy, V.

AU - Lewden, C.

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PY - 2014/11/1

Y1 - 2014/11/1

N2 - SETTING: Drug resistance threatens tuberculosis (TB) control, particularly among human immunodeficiency virus (HIV) infected persons. OBJECTIVE: To describe practices in the prevention and management of drug-resistant TB under antiretroviral therapy (ART) programs in lower-income countries. DESIGN: We used online questionnaires to collect program-level data on 47 ART programs in Southern Africa (n =14), East Africa (n = 8), West Africa (n = 7), Central Africa (n = 5), Latin America (n = 7) and the Asia-Pacific (n=6 programs) in 2012. Patient-level data were collected on 1002 adult TB patients seen at 40 of the participating ART programs. RESULTS: Phenotypic drug susceptibility testing (DST) was available in 36 (77%) ART programs, but was only used for 22% of all TB patients. Molecular DST was available in 33 (70%) programs and was used in 23% of all TB patients. Twenty ART programs (43%) provided directly observed therapy (DOT) during the entire course of treatment, 16 (34%) during the intensive phase only, and 11 (23%) did not follow DOT. Fourteen (30%) ART programs reported no access to second-line anti-tuberculosis regimens; 18 (38%) reported TB drug shortages. CONCLUSIONS: Capacity to diagnose and treat drugresistant TB was limited across ART programs in lowerincome countries. DOT was not always implemented and drug supplies were regularly interrupted, which may contribute to the global emergence of drug resistance.

AB - SETTING: Drug resistance threatens tuberculosis (TB) control, particularly among human immunodeficiency virus (HIV) infected persons. OBJECTIVE: To describe practices in the prevention and management of drug-resistant TB under antiretroviral therapy (ART) programs in lower-income countries. DESIGN: We used online questionnaires to collect program-level data on 47 ART programs in Southern Africa (n =14), East Africa (n = 8), West Africa (n = 7), Central Africa (n = 5), Latin America (n = 7) and the Asia-Pacific (n=6 programs) in 2012. Patient-level data were collected on 1002 adult TB patients seen at 40 of the participating ART programs. RESULTS: Phenotypic drug susceptibility testing (DST) was available in 36 (77%) ART programs, but was only used for 22% of all TB patients. Molecular DST was available in 33 (70%) programs and was used in 23% of all TB patients. Twenty ART programs (43%) provided directly observed therapy (DOT) during the entire course of treatment, 16 (34%) during the intensive phase only, and 11 (23%) did not follow DOT. Fourteen (30%) ART programs reported no access to second-line anti-tuberculosis regimens; 18 (38%) reported TB drug shortages. CONCLUSIONS: Capacity to diagnose and treat drugresistant TB was limited across ART programs in lowerincome countries. DOT was not always implemented and drug supplies were regularly interrupted, which may contribute to the global emergence of drug resistance.

KW - ART programs

KW - Africa

KW - Asia

KW - Latin America

KW - MDR-TB

UR - http://www.scopus.com/inward/record.url?scp=84908671644&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84908671644&partnerID=8YFLogxK

U2 - 10.5588/ijtld.14.0106

DO - 10.5588/ijtld.14.0106

M3 - Article

VL - 18

SP - 1327

EP - 1336

JO - International Journal of Tuberculosis and Lung Disease

JF - International Journal of Tuberculosis and Lung Disease

SN - 1027-3719

IS - 11

ER -