Detection by electron microscopy of R-type virus-like particles in chemically-induced hamster lingual carcinomas

T. Odajima*, D. B. Solt

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Electron microscopy revealed virus-like particles (VLP) in 5 of 12 squamous cell carcinomas induced in hamster tongue by topical application of 7,12-dimethylbenz(a)anthracene in acetone. The VLP morphology was characteristic of R-type VLP; VLP were exclusively within the cisternae of the rough endoplasmic reticulum of cancer cells. No VLP were detected in non-tumourous control tissues. On the basis of the ultrastructural appearances, a scheme of the morphogenesis of R-type VLP is proposed.

Original languageEnglish (US)
Pages (from-to)1075-1079
Number of pages5
JournalArchives of Oral Biology
Volume27
Issue number12
DOIs
StatePublished - 1982

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Dentistry(all)
  • Cell Biology

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