Detection of 6q deletions in breast carcinoma cell lines by fluorescence in situ hybridization

Yanming Zhang, Peter Matthiesen, Reiner Siebert, Svetlana Harder, Michael Theile, Siegfried Scherneck, Brigitte Schlegelberger*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Dual-color fluorescence in situ hybridization was performed to detect the frequency and extent of 6q deletions in ten breast carcinoma cell lines. In five cell lines, the 6q deletions involved large regions extending from 6q12-q16 to 6q27, and in one the deletion extended from the region distal to YAC 751G10 at 6q25.1 to 6q27. In two cell lines, 6q deletions occurred only in cells with polysomy 6, indicating that such deletions might be secondary chromosomal aberrations and reflect late genetic changes in breast carcinomas. In addition, an overrepresentation of 6q21-q22.2 was detected in one cell line.

Original languageEnglish (US)
Pages (from-to)727-729
Number of pages3
JournalHuman Genetics
Volume103
Issue number6
DOIs
StatePublished - Dec 1 1998

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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