Detection of early cancer and pre-cancer with scattered light

L. T. Perelman; V. Backman

doi:10.1117/12.431516

Detection of early cancer and pre-cancer with scattered light

L. T. Perelman^*, V. Backman

^*Corresponding author for this work

Biomedical Engineering

Research output: Contribution to journal › Conference article

1 Scopus citations

Abstract

The light scattering spectroscopy (LSS) of biological tissue aims to distinguish between single scattering from the cell structures such as cell nuclei located near the tissue surface and multiply scattered light (diffusive background). The spectrum of the single scattering component can be further analyzed to provide histological information about the uppermost cells, such as the size distribution of the cell nuclei. Experiments are presented which show that polarized LSS is capable of extracting morphological information from living cells in the presence of the large background from underlying tissue.

Original language	English (US)
Pages (from-to)	162-167
Number of pages	6
Journal	Proceedings of SPIE - The International Society for Optical Engineering
Volume	4241
DOIs	https://doi.org/10.1117/12.431516
State	Published - Jan 1 2001
Event	Saratov Fall Meeting 2000 Optical Technologies in Biophysics and Medicine II - Saratov, Russian Federation Duration: Oct 3 2000 → Oct 6 2000

ASJC Scopus subject areas

Electrical and Electronic Engineering
Condensed Matter Physics

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Perelman, L. T., & Backman, V. (2001). Detection of early cancer and pre-cancer with scattered light. Proceedings of SPIE - The International Society for Optical Engineering, 4241, 162-167. https://doi.org/10.1117/12.431516

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abstract = "The light scattering spectroscopy (LSS) of biological tissue aims to distinguish between single scattering from the cell structures such as cell nuclei located near the tissue surface and multiply scattered light (diffusive background). The spectrum of the single scattering component can be further analyzed to provide histological information about the uppermost cells, such as the size distribution of the cell nuclei. Experiments are presented which show that polarized LSS is capable of extracting morphological information from living cells in the presence of the large background from underlying tissue.",

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