Detection of early response to temozolomide treatment in brain tumors using hyperpolarized 13C MR metabolic imaging

Ilwoo Park*, Robert Bok, Tomoko Ozawa, Joanna J. Phillips, C. David James, Daniel B. Vigneron, Sabrina M. Ronen, Sarah J. Nelson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

93 Scopus citations

Abstract

Purpose: To demonstrate the feasibility of using DNP hyperpolarized [1-13C]-pyruvate to measure early response to temozolomide (TMZ) therapy using an orthotopic human glioblastoma xenograft model. Materials and Methods: Twenty athymic rats with intracranial implantation of human glioblastoma cells were divided into two groups: one group received an oral administration of 100 mg/kg TMZ (n = 10) and the control group received vehicle only (n = 10). 13C 3D magnetic resonance spectroscopic imaging (MRSI) data were acquired following injection of 2.5 mL (100 mM) hyperpolarized [1-13C]-pyruvate using a 3T scanner prior to treatment (day D0), at D1 (days from treatment) or D2. Results: Tumor metabolism as assessed by the ratio of lactate to pyruvate (Lac/Pyr) was significantly altered at D1 for the TMZ-treated group but tumor volume did not show a reduction until D5 to D7. The percent change in Lac/Pyr from baseline was statistically different between the two groups at D1 and D2 (P < 0.008), while percent tumor volume was not (P > 0.2). Conclusion: The results from this study suggest that metabolic imaging with hyperpolarized [1-13C]-pyruvate may provide a unique tool that clinical neuro-oncologists can use in the future to monitor tumor response to therapy for patients with brain tumors.

Original languageEnglish (US)
Pages (from-to)1284-1290
Number of pages7
JournalJournal of Magnetic Resonance Imaging
Volume33
Issue number6
DOIs
StatePublished - Jun 2011

Keywords

  • brain tumor
  • dynamic nuclear polarization
  • hyperpolarized C MRSI
  • response to temozolomide

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Fingerprint

Dive into the research topics of 'Detection of early response to temozolomide treatment in brain tumors using hyperpolarized <sup>13</sup>C MR metabolic imaging'. Together they form a unique fingerprint.

Cite this