TY - JOUR
T1 - Detection of HLA and MICA antibodies before kidney graft failure.
AU - Mizutani, Kazuo
AU - Shibata, Lina
AU - Ozawa, Mikki
AU - Esquenazi, Violet
AU - Rosen, Anne
AU - Miller, Joshua
AU - Terasaki, Paul I.
PY - 2006
Y1 - 2006
N2 - 390 serum samples taken from a series of 28 patients who lost their grafts were retrospectively investigated for antibodies by single antigen HLA Class I&II and MICA Luminex beads. In 20 patients with immunological failure, 10 patients had DSA, 16 had epitope-related NDSA, and 16 had NDSA or MICA antibodies. In 16 which increased antibodies leading up to the graft failure, DSA were found in 7 patients. However, in 9 patients who similarly rejected their grafts, 6 were epitope-related DSA and 3 were NDSA. We were unable to establish why NDSA might be associated with the failure, but this was clearly the case in these patients. Of the 25 patients whose grafts were rejected, 23 (92%) produced antibody prior to failure. Our results strongly suggest that antibody monitoring is important as a means of detecting chronic rejection before a rise in SCr. Early detection of antibody would allow for appropriate and timely interventions to save a graft.
AB - 390 serum samples taken from a series of 28 patients who lost their grafts were retrospectively investigated for antibodies by single antigen HLA Class I&II and MICA Luminex beads. In 20 patients with immunological failure, 10 patients had DSA, 16 had epitope-related NDSA, and 16 had NDSA or MICA antibodies. In 16 which increased antibodies leading up to the graft failure, DSA were found in 7 patients. However, in 9 patients who similarly rejected their grafts, 6 were epitope-related DSA and 3 were NDSA. We were unable to establish why NDSA might be associated with the failure, but this was clearly the case in these patients. Of the 25 patients whose grafts were rejected, 23 (92%) produced antibody prior to failure. Our results strongly suggest that antibody monitoring is important as a means of detecting chronic rejection before a rise in SCr. Early detection of antibody would allow for appropriate and timely interventions to save a graft.
UR - http://www.scopus.com/inward/record.url?scp=43549089337&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=43549089337&partnerID=8YFLogxK
M3 - Article
C2 - 18365383
AN - SCOPUS:43549089337
SN - 0890-9016
SP - 255
EP - 264
JO - Clinical transplants
JF - Clinical transplants
ER -