Detection of immunoglobulin G antibody to purified protein derivative in patients with tuberculosis by radioimmunoassay and enzyme-linked immunosorbent assay

C. R. Zeiss, R. C. Radin, J. E. Williams, D. Levitz, J. P. Phair

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Sera from patients with active tuberculosis and sera from appropriate control individuals were assayed for immunoglobulin G antibody activity to purified protein derivative by a polystyrene tube radioimmunoassay and an enzyme-linked immunosorbent assay. Both assays showed a marked increase in immunoglobulin G antibody activity in patients with active tuberculosis. There was not overlap between the values for the patient group and the values for the purified protein derivative skin test-positive control individuals. The replication of these assays was excellent, and both could provide quantitative measurements of immunoglobulin G antibody activity to purified protein derivative antigen within 24 h. These techniques have potential as rapid diagnostic aids in evaluating patients with suspected active tuberculosis.

Original languageEnglish (US)
Pages (from-to)93-96
Number of pages4
JournalUnknown Journal
Volume15
Issue number1
DOIs
StatePublished - 1982

ASJC Scopus subject areas

  • Microbiology (medical)

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