Detection of infection with human immunedeficiency virus type 1 before seroconversion: Correlation with clinical symptoms and outcome

John P. Phair*, Joseph B. Margolick, Lisa P. Jacobson, Jack Phillips, Charles Rinaldo, Richard Kaslow, Clara Chu, Janis V. Giorgi, Denis Henrard

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Early (pre-seroconversion) infection with human immunodeficiency virus type 1 (HIV-1) was identified in 50 of 267 participants in the Multicenter AIDS Cohort Study. These 50 men had a positive EIA result, which detected IgM antibody (n = 35), p24 antigen, or serum HIV RNA (n = 15) at their last 'seronegative' visit. At that visit, the mean CD4 lymphocyte number (890/mm3 vs. 1038/mm3) was significantly lower than in men who subsequently seroconverted but had no evidence of early infection. The decline in CD4 cells was slower and the duration of AIDS-free time longer in the 19 men who were symptomatic in comparison to the 31 asymptomatic men with early infection, but differences were not significant.

Original languageEnglish (US)
Pages (from-to)959-962
Number of pages4
JournalJournal of Infectious Diseases
Volume175
Issue number4
DOIs
StatePublished - 1997

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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