Detection of neurologic injury using vascular reactivity monitoring and glial fibrillary acidic protein

Christopher J. Rhee*, Kathleen K. Kibler, Kenneth Martin Brady, Allen D. Everett, Ernest M. Graham, Dean B. Andropoulos, R. Blaine Easley

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


New noninvasive methods for monitoring cerebrovascular pressure reactivity coupled with a blood-based assay for brain-specific injury in preterm infants could allow early diagnosis of brain injury and set the stage for improved timing and effectiveness of interventions. Using an adaptation of near-infrared spectroscopy, we report a case of a very low birth weight infant undergoing hemoglobin volume index monitoring as a measure of cerebrovascular pressure reactivity. During the monitoring period, this infant demonstrated significant disturbances in cerebrovascular pressure reactivity that coincided with elevation of serum glial fibrillary acidic protein and new findings of brain injury on head ultrasound. This case report demonstrates the potential of emerging noninvasive monitoring methods to assist in both detection and therapeutic management to improve neurologic outcomes of the very low birth weight neonate.

Original languageEnglish (US)
Pages (from-to)e950-e954
Issue number3
StatePublished - Mar 2013


  • Cerebrovascular pressure reactivity
  • Glial fibrillary acidic protein
  • Head ultrasound
  • Intraventricular hemorrhage
  • Prematurity
  • Very low birth weight

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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