Abstract
Releasing individuals from susceptibility to and anxiety about the development of cancer is an eventual goal of cancer research. This owes much to rapid progress in molecular oncology that is supported by advances in technology. Cancers of the colon and rectum, pancreas and lung that share certain clinical and molecular oncological characteristics represent timely and important target of this field. Of the genes altered in these types of cancers, the best documented is K-ras. Currently highlighted along with this oncogene is β-catenin, which has roles in both cell adhesion and transformation. Molecular diagnosis and susceptibility assessment targeting of such oncogenes will be promising for Improvement in treatment and prevention of cancer, thereby contributing to human healthcare. Here we review recent knowledge on molecular diagnosis of sporadic cancers, with focus on K-ras and β-catenin oncogenes.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 565-575 |
| Number of pages | 11 |
| Journal | Expert Review of Molecular Diagnostics |
| Volume | 2 |
| Issue number | 6 |
| DOIs | |
| State | Published - Nov 2002 |
Funding
This work was supported in part by Grants-in-Aids for Cancer Research from the Ministry of Education, Science, Sports and Culture of Japan (to Minamoto T and Mai M) and a grant from the Japan Society for the Promotion of Science (to Minamoto T and Ougolkov AV). Grants from the Hokkoku Cancer Research Promotion Foundation (to Minamoto T) and from the Kanazawa Research Center for Advanced Technology (to Minamoto T) were also appreciated.
Keywords
- Cancer
- Colon and rectum
- Diagnosis
- K-ras
- Lung
- Oncogene
- Pancreas
- β-catenin
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Molecular Medicine
- Molecular Biology
- Genetics
