Determinant of left atrial dilation in patients with hypertrophic cardiomyopathy: A real-time 3-dimensional echocardiographic study

Fabrice Bauer, Takahiro Shiota*, Richard D. White, Harry M. Lever, Jian Xin Qin, Jeannie Drinko, Maureen Martin, Hiroyuki Tsujino, Marta Sitges, Yong Jin Kim, James D. Thomas

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

38 Scopus citations

Abstract

To identify the determinants of left atrial (LA) dilation for patients with hypertrophic obstructive cardiomyopathy (HOCM), first we validated LA volume determination by real-time 3-dimensional echocardiography using magnetic resonance imaging in patients. Subsequently, real-time 3-dimensional echocardiography and 2-dimensional Doppler echocardiography were performed in 60 patients with HOCM and in 17 age-matched control subjects. LA volumes and left ventricular (LV) filling pressures were higher for patients with HOCM than in control subjects. By stepwise multilinear regression analysis, LV end-diastolic pressure, resting LV outflow tract pressure gradient, and LV wall thickness were significant determinants of LA dilation. However, τ, -dP/dt, LV stiffness, provokable pressure gradient, and mitral regurgitation did not have any independent relationship with LA volumes. Therefore, it is concluded that LA volume can be accurately determined by real-time 3-dimensional echocardiography; and LA dilation in patients with HOCM is related to LV filling pressure, LV outflow tract pressure gradient, and LV wall thickness.

Original languageEnglish (US)
Pages (from-to)968-975
Number of pages8
JournalJournal of the American Society of Echocardiography
Volume17
Issue number9
DOIs
StatePublished - Sep 2004

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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