TY - JOUR
T1 - Determinant of left atrial dilation in patients with hypertrophic cardiomyopathy
T2 - A real-time 3-dimensional echocardiographic study
AU - Bauer, Fabrice
AU - Shiota, Takahiro
AU - White, Richard D.
AU - Lever, Harry M.
AU - Qin, Jian Xin
AU - Drinko, Jeannie
AU - Martin, Maureen
AU - Tsujino, Hiroyuki
AU - Sitges, Marta
AU - Kim, Yong Jin
AU - Thomas, James D.
N1 - Funding Information:
Supported in part by grant of Fédération Française de Cardiologie, Paris, France, and grant NCC9-60 and NCC9-58, National Aeronautics and Space Administration, Houston, Texas.
PY - 2004/9
Y1 - 2004/9
N2 - To identify the determinants of left atrial (LA) dilation for patients with hypertrophic obstructive cardiomyopathy (HOCM), first we validated LA volume determination by real-time 3-dimensional echocardiography using magnetic resonance imaging in patients. Subsequently, real-time 3-dimensional echocardiography and 2-dimensional Doppler echocardiography were performed in 60 patients with HOCM and in 17 age-matched control subjects. LA volumes and left ventricular (LV) filling pressures were higher for patients with HOCM than in control subjects. By stepwise multilinear regression analysis, LV end-diastolic pressure, resting LV outflow tract pressure gradient, and LV wall thickness were significant determinants of LA dilation. However, τ, -dP/dt, LV stiffness, provokable pressure gradient, and mitral regurgitation did not have any independent relationship with LA volumes. Therefore, it is concluded that LA volume can be accurately determined by real-time 3-dimensional echocardiography; and LA dilation in patients with HOCM is related to LV filling pressure, LV outflow tract pressure gradient, and LV wall thickness.
AB - To identify the determinants of left atrial (LA) dilation for patients with hypertrophic obstructive cardiomyopathy (HOCM), first we validated LA volume determination by real-time 3-dimensional echocardiography using magnetic resonance imaging in patients. Subsequently, real-time 3-dimensional echocardiography and 2-dimensional Doppler echocardiography were performed in 60 patients with HOCM and in 17 age-matched control subjects. LA volumes and left ventricular (LV) filling pressures were higher for patients with HOCM than in control subjects. By stepwise multilinear regression analysis, LV end-diastolic pressure, resting LV outflow tract pressure gradient, and LV wall thickness were significant determinants of LA dilation. However, τ, -dP/dt, LV stiffness, provokable pressure gradient, and mitral regurgitation did not have any independent relationship with LA volumes. Therefore, it is concluded that LA volume can be accurately determined by real-time 3-dimensional echocardiography; and LA dilation in patients with HOCM is related to LV filling pressure, LV outflow tract pressure gradient, and LV wall thickness.
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U2 - 10.1016/j.echo.2004.05.018
DO - 10.1016/j.echo.2004.05.018
M3 - Article
C2 - 15337962
AN - SCOPUS:4444352917
SN - 0894-7317
VL - 17
SP - 968
EP - 975
JO - Journal of the American Society of Echocardiography
JF - Journal of the American Society of Echocardiography
IS - 9
ER -