Determinants and role of chromatin organization in acute leukemia

Celestia Fang, Sridhar Rao, John D. Crispino*, Panagiotis Ntziachristos

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

DNA is compacted into higher order structures that have major implications in gene regulation. These structures allow for long-range interactions of DNA elements, such as the association of promoters with their cognate enhancers. In recent years, mutations in genes that control these structures, including the cohesin-complex and the insulator-binding protein CTCF, have been found in a spectrum of hematologic disorders, and especially in acute leukemias. Cohesin and CTCF are critical for mediating looping and establishing boundaries within chromatin. Cells that harbor mutations in these genes display aberrant chromatin architecture and resulting differences in gene expression that contribute to leukemia initiation and progression. Here, we provide detailed discussion of the nature of 3D interactions and the way that they are disrupted in acute leukemia. Continued research in this area will provide new insights into the mechanisms of leukemogenesis and may shed light on novel treatment strategies.

Original languageEnglish (US)
Pages (from-to)2561-2575
Number of pages15
JournalLeukemia
Volume34
Issue number10
DOIs
StatePublished - Oct 1 2020

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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