Determinants of drug disposition and effect in the fetus

T. P. Green, R. F. O'Dea, B. L. Mirkin

Research output: Contribution to journalArticlepeer-review

46 Scopus citations


This review considers aspects of developmental pharmacology that have not been extensively considered in previous publications, examining in particular the following subject areas: The determinants of placental transfer with emphasis on how biological maturation modifies these factors and influences fetal drug disposition. The fetal hepatic circulation and its effect on drug metabolism. The role of the adenyl cyclase-cyclic nucleotide system in regulating receptor reactivity and the fetal response to drugs.

Original languageEnglish (US)
Pages (from-to)285-322
Number of pages38
JournalAnnual Review of Pharmacology and Toxicology
VolumeVol. 19
StatePublished - 1979
Externally publishedYes

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology


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