Determinants of the development of mitral regurgitation in pacing-induced heart failure

Masami Takagaki; Patrick M. McCarthy; Marlene Goormastic; Yoshie Ochiai; Kazuyoshi Doi; Michael W. Kopcak; Tomotsugu Tabata; Lisa A. Cardon; James D. Thomas; Kiyotaka Fukamachi

doi:10.1253/circj.67.78

Determinants of the development of mitral regurgitation in pacing-induced heart failure

Masami Takagaki, Patrick M. McCarthy, Marlene Goormastic, Yoshie Ochiai, Kazuyoshi Doi, Michael W. Kopcak, Tomotsugu Tabata, Lisa A. Cardon, James D. Thomas, Kiyotaka Fukamachi^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

The pacing-induced heart failure model provides an opportunity to assess the structural and functional determinants of mitral regurgitation (MR) in dilated cardiomyopathy. This study aimed to evaluate MR to better understand the multitude of factors contributing to its development. Heart failure was induced by rapid ventricular pacing (230 beats/min) in 40 mongrel dogs. Left ventricular (LV) size and MR were evaluated echocardiographically. LV contractility was analyzed using a conductance catheter. MR increased to mild in 12 animals (regurgitant orifice area, 0.06±0.05 cm²), moderate in 15 (0.14±0.07 cm²), and severe in 13 (0.34±0.16 cm²). The grade of MR had an inverse relationships with Emax (the slope of the end-systolic pressure-volume relationship, p<0.01) and dE/dt (the slope of the maximum rate of change of pressure-end-diastolic volume [V ED] relationship, p<0.01) and positive relationships with V ED and end-diastolic cross-sectional areas and lengths (p<0.05) by univariate analysis. The dE/dt had an independently significant (p<0.01) relationship by multivariable logistic regression. Many factors influence the development of MR and because of its similarity to the clinical situation, this model can be used to investigate MR and heart failure, as well as new surgical therapies.

Original language	English (US)
Pages (from-to)	78-82
Number of pages	5
Journal	Circulation Journal
Volume	67
Issue number	1
DOIs	https://doi.org/10.1253/circj.67.78
State	Published - Jan 1 2003

Keywords

Contractility
Heart failure
Mitral valve
Pacing
Regurgitation

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

Access to Document

10.1253/circj.67.78

Cite this

@article{8b59ec95f8a5422fa52bbd2c13e59713,

title = "Determinants of the development of mitral regurgitation in pacing-induced heart failure",

abstract = "The pacing-induced heart failure model provides an opportunity to assess the structural and functional determinants of mitral regurgitation (MR) in dilated cardiomyopathy. This study aimed to evaluate MR to better understand the multitude of factors contributing to its development. Heart failure was induced by rapid ventricular pacing (230 beats/min) in 40 mongrel dogs. Left ventricular (LV) size and MR were evaluated echocardiographically. LV contractility was analyzed using a conductance catheter. MR increased to mild in 12 animals (regurgitant orifice area, 0.06±0.05 cm2), moderate in 15 (0.14±0.07 cm2), and severe in 13 (0.34±0.16 cm2). The grade of MR had an inverse relationships with Emax (the slope of the end-systolic pressure-volume relationship, p<0.01) and dE/dt (the slope of the maximum rate of change of pressure-end-diastolic volume [V ED] relationship, p<0.01) and positive relationships with V ED and end-diastolic cross-sectional areas and lengths (p<0.05) by univariate analysis. The dE/dt had an independently significant (p<0.01) relationship by multivariable logistic regression. Many factors influence the development of MR and because of its similarity to the clinical situation, this model can be used to investigate MR and heart failure, as well as new surgical therapies.",

keywords = "Contractility, Heart failure, Mitral valve, Pacing, Regurgitation",

author = "Masami Takagaki and McCarthy, {Patrick M.} and Marlene Goormastic and Yoshie Ochiai and Kazuyoshi Doi and Kopcak, {Michael W.} and Tomotsugu Tabata and Cardon, {Lisa A.} and Thomas, {James D.} and Kiyotaka Fukamachi",

year = "2003",

month = jan,

day = "1",

doi = "10.1253/circj.67.78",

language = "English (US)",

volume = "67",

pages = "78--82",

journal = "Circulation Journal",

issn = "1346-9843",

publisher = "Japanese Circulation Society",

number = "1",

}

TY - JOUR

T1 - Determinants of the development of mitral regurgitation in pacing-induced heart failure

AU - Takagaki, Masami

AU - McCarthy, Patrick M.

AU - Goormastic, Marlene

AU - Ochiai, Yoshie

AU - Doi, Kazuyoshi

AU - Kopcak, Michael W.

AU - Tabata, Tomotsugu

AU - Cardon, Lisa A.

AU - Thomas, James D.

AU - Fukamachi, Kiyotaka

PY - 2003/1/1

Y1 - 2003/1/1

N2 - The pacing-induced heart failure model provides an opportunity to assess the structural and functional determinants of mitral regurgitation (MR) in dilated cardiomyopathy. This study aimed to evaluate MR to better understand the multitude of factors contributing to its development. Heart failure was induced by rapid ventricular pacing (230 beats/min) in 40 mongrel dogs. Left ventricular (LV) size and MR were evaluated echocardiographically. LV contractility was analyzed using a conductance catheter. MR increased to mild in 12 animals (regurgitant orifice area, 0.06±0.05 cm2), moderate in 15 (0.14±0.07 cm2), and severe in 13 (0.34±0.16 cm2). The grade of MR had an inverse relationships with Emax (the slope of the end-systolic pressure-volume relationship, p<0.01) and dE/dt (the slope of the maximum rate of change of pressure-end-diastolic volume [V ED] relationship, p<0.01) and positive relationships with V ED and end-diastolic cross-sectional areas and lengths (p<0.05) by univariate analysis. The dE/dt had an independently significant (p<0.01) relationship by multivariable logistic regression. Many factors influence the development of MR and because of its similarity to the clinical situation, this model can be used to investigate MR and heart failure, as well as new surgical therapies.

AB - The pacing-induced heart failure model provides an opportunity to assess the structural and functional determinants of mitral regurgitation (MR) in dilated cardiomyopathy. This study aimed to evaluate MR to better understand the multitude of factors contributing to its development. Heart failure was induced by rapid ventricular pacing (230 beats/min) in 40 mongrel dogs. Left ventricular (LV) size and MR were evaluated echocardiographically. LV contractility was analyzed using a conductance catheter. MR increased to mild in 12 animals (regurgitant orifice area, 0.06±0.05 cm2), moderate in 15 (0.14±0.07 cm2), and severe in 13 (0.34±0.16 cm2). The grade of MR had an inverse relationships with Emax (the slope of the end-systolic pressure-volume relationship, p<0.01) and dE/dt (the slope of the maximum rate of change of pressure-end-diastolic volume [V ED] relationship, p<0.01) and positive relationships with V ED and end-diastolic cross-sectional areas and lengths (p<0.05) by univariate analysis. The dE/dt had an independently significant (p<0.01) relationship by multivariable logistic regression. Many factors influence the development of MR and because of its similarity to the clinical situation, this model can be used to investigate MR and heart failure, as well as new surgical therapies.

KW - Contractility

KW - Heart failure

KW - Mitral valve

KW - Pacing

KW - Regurgitation

UR - http://www.scopus.com/inward/record.url?scp=12244274953&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=12244274953&partnerID=8YFLogxK

U2 - 10.1253/circj.67.78

DO - 10.1253/circj.67.78

M3 - Article

C2 - 12520157

AN - SCOPUS:12244274953

SN - 1346-9843

VL - 67

SP - 78

EP - 82

JO - Circulation Journal

JF - Circulation Journal

IS - 1

ER -

Determinants of the development of mitral regurgitation in pacing-induced heart failure

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this