Determine Whether Norepinephrine Amplifies the Commands of Indirect Motor Pathways

Margaret Sereika*, Thomas Plaisier, James A. Beauchamp, Jun Yao, Julius P.A. Dewald

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Previous research has found upper limb impairments in stroke may be related to increased presence of norepinephrine at the spinal cord. However, no prior research has investigated how decreasing norepinephrine(NE) changes cortical activity and the use of descending pathways. After administering a single dose of Tizanidine (TIZ), to decrease NE, preliminary results found increased connectivity between lesional hemisphere and paretic arm. This clinical trial is currently being conducted on a larger stroke population in a double-blinded manner.

Original languageEnglish (US)
Title of host publicationBiosystems and Biorobotics
PublisherSpringer Science and Business Media Deutschland GmbH
Pages147-150
Number of pages4
DOIs
StatePublished - 2025

Publication series

NameBiosystems and Biorobotics
Volume34
ISSN (Print)2195-3562
ISSN (Electronic)2195-3570

ASJC Scopus subject areas

  • Biomedical Engineering
  • Mechanical Engineering
  • Artificial Intelligence

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