Determining the Differential Effects of Stretch and Growth in Tissue-Expanded Skin: Combining Isogeometric Analysis and Continuum Mechanics in a Porcine Model

Chad A. Purnell; Michael S. Gart; Adrián Buganza-Tepole; Joanna P. Tomaszewski; Jolanta M Topczewska; Ellen Kuhl; Arun Kumar Gosain

doi:10.1097/DSS.0000000000001228

Determining the Differential Effects of Stretch and Growth in Tissue-Expanded Skin: Combining Isogeometric Analysis and Continuum Mechanics in a Porcine Model

Chad A. Purnell, Michael S. Gart, Adrián Buganza-Tepole, Joanna P. Tomaszewski, Jolanta M Topczewska, Ellen Kuhl, Arun Kumar Gosain

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

BACKGROUND: The relative effects of skin growth and stretch during tissue expansion have not been studied. The authors use novel analytic techniques that allow calculation of these factors at any point of a skin patch.

OBJECTIVE: The authors sought to determine how stretch and growth change with different expansion rates and to correlate these values with histologic and cellular changes in skin.

MATERIALS AND METHODS: Two minipigs were implanted with a total of 5 tissue expanders under tattooed skin grids. One pig was expanded over 35 days and the second over 15 days. Isogeometric analysis allowed calculation of growth and stretch. Expanders with similar total deformation were compared between protocols. Regression analysis determined predictive effects of stretch and growth on histologic data from the second animal.

RESULTS: Deformation was more attributable to stretch in rapid than in slow expansion (1.40 vs1.12, p < .001). Growth was higher in slow expansion than in rapid (1.52 vs 1.07, p < .001). Both growth and stretch predicted epidermal thickness, dermal thinning, and keratinocyte proliferation. Growth predicted vascularity.

CONCLUSION: Isogeometric analysis allows determination of precise surface area changes for correlation to microscopic-level data. Using the model, the authors identified that skin deformation in rapid expansion is more attributable to stretch.

Original language	English (US)
Pages (from-to)	48-52
Number of pages	5
Journal	Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
Volume	44
Issue number	1
DOIs	https://doi.org/10.1097/DSS.0000000000001228
State	Published - Jan 1 2018

ASJC Scopus subject areas

Surgery
Dermatology

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Purnell, C. A., Gart, M. S., Buganza-Tepole, A., Tomaszewski, J. P., Topczewska, J. M., Kuhl, E., & Gosain, A. K. (2018). Determining the Differential Effects of Stretch and Growth in Tissue-Expanded Skin: Combining Isogeometric Analysis and Continuum Mechanics in a Porcine Model. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 44(1), 48-52. https://doi.org/10.1097/DSS.0000000000001228

Purnell, Chad A. ; Gart, Michael S. ; Buganza-Tepole, Adrián ; Tomaszewski, Joanna P. ; Topczewska, Jolanta M ; Kuhl, Ellen ; Gosain, Arun Kumar. / Determining the Differential Effects of Stretch and Growth in Tissue-Expanded Skin : Combining Isogeometric Analysis and Continuum Mechanics in a Porcine Model. In: Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]. 2018 ; Vol. 44, No. 1. pp. 48-52.

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title = "Determining the Differential Effects of Stretch and Growth in Tissue-Expanded Skin: Combining Isogeometric Analysis and Continuum Mechanics in a Porcine Model",

abstract = "BACKGROUND: The relative effects of skin growth and stretch during tissue expansion have not been studied. The authors use novel analytic techniques that allow calculation of these factors at any point of a skin patch.OBJECTIVE: The authors sought to determine how stretch and growth change with different expansion rates and to correlate these values with histologic and cellular changes in skin.MATERIALS AND METHODS: Two minipigs were implanted with a total of 5 tissue expanders under tattooed skin grids. One pig was expanded over 35 days and the second over 15 days. Isogeometric analysis allowed calculation of growth and stretch. Expanders with similar total deformation were compared between protocols. Regression analysis determined predictive effects of stretch and growth on histologic data from the second animal.RESULTS: Deformation was more attributable to stretch in rapid than in slow expansion (1.40 vs1.12, p < .001). Growth was higher in slow expansion than in rapid (1.52 vs 1.07, p < .001). Both growth and stretch predicted epidermal thickness, dermal thinning, and keratinocyte proliferation. Growth predicted vascularity.CONCLUSION: Isogeometric analysis allows determination of precise surface area changes for correlation to microscopic-level data. Using the model, the authors identified that skin deformation in rapid expansion is more attributable to stretch.",

author = "Purnell, {Chad A.} and Gart, {Michael S.} and Adri{\'a}n Buganza-Tepole and Tomaszewski, {Joanna P.} and Topczewska, {Jolanta M} and Ellen Kuhl and Gosain, {Arun Kumar}",

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Purnell, CA, Gart, MS, Buganza-Tepole, A, Tomaszewski, JP, Topczewska, JM, Kuhl, E & Gosain, AK 2018, 'Determining the Differential Effects of Stretch and Growth in Tissue-Expanded Skin: Combining Isogeometric Analysis and Continuum Mechanics in a Porcine Model', Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], vol. 44, no. 1, pp. 48-52. https://doi.org/10.1097/DSS.0000000000001228

Determining the Differential Effects of Stretch and Growth in Tissue-Expanded Skin : Combining Isogeometric Analysis and Continuum Mechanics in a Porcine Model. / Purnell, Chad A.; Gart, Michael S.; Buganza-Tepole, Adrián; Tomaszewski, Joanna P.; Topczewska, Jolanta M; Kuhl, Ellen; Gosain, Arun Kumar.

In: Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], Vol. 44, No. 1, 01.01.2018, p. 48-52.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Determining the Differential Effects of Stretch and Growth in Tissue-Expanded Skin

T2 - Combining Isogeometric Analysis and Continuum Mechanics in a Porcine Model

AU - Purnell, Chad A.

AU - Gart, Michael S.

AU - Buganza-Tepole, Adrián

AU - Tomaszewski, Joanna P.

AU - Topczewska, Jolanta M

AU - Kuhl, Ellen

AU - Gosain, Arun Kumar

PY - 2018/1/1

Y1 - 2018/1/1

N2 - BACKGROUND: The relative effects of skin growth and stretch during tissue expansion have not been studied. The authors use novel analytic techniques that allow calculation of these factors at any point of a skin patch.OBJECTIVE: The authors sought to determine how stretch and growth change with different expansion rates and to correlate these values with histologic and cellular changes in skin.MATERIALS AND METHODS: Two minipigs were implanted with a total of 5 tissue expanders under tattooed skin grids. One pig was expanded over 35 days and the second over 15 days. Isogeometric analysis allowed calculation of growth and stretch. Expanders with similar total deformation were compared between protocols. Regression analysis determined predictive effects of stretch and growth on histologic data from the second animal.RESULTS: Deformation was more attributable to stretch in rapid than in slow expansion (1.40 vs1.12, p < .001). Growth was higher in slow expansion than in rapid (1.52 vs 1.07, p < .001). Both growth and stretch predicted epidermal thickness, dermal thinning, and keratinocyte proliferation. Growth predicted vascularity.CONCLUSION: Isogeometric analysis allows determination of precise surface area changes for correlation to microscopic-level data. Using the model, the authors identified that skin deformation in rapid expansion is more attributable to stretch.

AB - BACKGROUND: The relative effects of skin growth and stretch during tissue expansion have not been studied. The authors use novel analytic techniques that allow calculation of these factors at any point of a skin patch.OBJECTIVE: The authors sought to determine how stretch and growth change with different expansion rates and to correlate these values with histologic and cellular changes in skin.MATERIALS AND METHODS: Two minipigs were implanted with a total of 5 tissue expanders under tattooed skin grids. One pig was expanded over 35 days and the second over 15 days. Isogeometric analysis allowed calculation of growth and stretch. Expanders with similar total deformation were compared between protocols. Regression analysis determined predictive effects of stretch and growth on histologic data from the second animal.RESULTS: Deformation was more attributable to stretch in rapid than in slow expansion (1.40 vs1.12, p < .001). Growth was higher in slow expansion than in rapid (1.52 vs 1.07, p < .001). Both growth and stretch predicted epidermal thickness, dermal thinning, and keratinocyte proliferation. Growth predicted vascularity.CONCLUSION: Isogeometric analysis allows determination of precise surface area changes for correlation to microscopic-level data. Using the model, the authors identified that skin deformation in rapid expansion is more attributable to stretch.

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U2 - 10.1097/DSS.0000000000001228

DO - 10.1097/DSS.0000000000001228

M3 - Article

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JO - Dermatologic Surgery

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SN - 1076-0512

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Purnell CA, Gart MS, Buganza-Tepole A, Tomaszewski JP, Topczewska JM, Kuhl E et al. Determining the Differential Effects of Stretch and Growth in Tissue-Expanded Skin: Combining Isogeometric Analysis and Continuum Mechanics in a Porcine Model. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]. 2018 Jan 1;44(1):48-52. https://doi.org/10.1097/DSS.0000000000001228

Determining the Differential Effects of Stretch and Growth in Tissue-Expanded Skin: Combining Isogeometric Analysis and Continuum Mechanics in a Porcine Model

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