Determining the shape and cellular distribution of mitochondria: The integration of multiple activities

Laura L. Lackner*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

28 Scopus citations

Abstract

Both mitochondrial and cellular function are influenced by the overall structure and position of mitochondria within cells. Proper mitochondrial structure and position are achieved through the concerted actions of multiple activities. These include mitochondrial dynamics, motility and tethering. Mitochondrial dynamics and motility facilitate transport of the organelle, while tethering pathways serve to stably position mitochondria at specific cellular sites. Recent studies have advanced our understanding of the molecular mechanisms underlying the activities that shape and position the mitochondrial network and have identified the ER as an active participant in many of these activities.

Original languageEnglish (US)
Pages (from-to)471-476
Number of pages6
JournalCurrent Opinion in Cell Biology
Volume25
Issue number4
DOIs
StatePublished - 2013

ASJC Scopus subject areas

  • Cell Biology

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