Deubiquitinases: Pro-oncogenic Activity and Therapeutic Targeting in Blood Malignancies

Blanca T. Gutierrez-Diaz, Wei Gu, Panagiotis Ntziachristos*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations

Abstract

Deubiquitinases are enzymes that remove ubiquitin moieties from the vast majority of cellular proteins, controlling their stability, interactions, and localization. The expression and activity of deubiquitinases are critical for physiology and can go awry in various diseases, including cancer. Based on recent findings in human blood cancers, we discuss the functions of selected deubiquitinases in acute leukemia and efforts to target these enzymes with the aim of blocking leukemia growth and improving disease outcomes. We focus on the emergence of the newest generation of preclinical inhibitors by discussing their modes of inhibition and their effects on leukemia biology.

Original languageEnglish (US)
Pages (from-to)327-340
Number of pages14
JournalTrends in Immunology
Volume41
Issue number4
DOIs
StatePublished - Apr 2020

Funding

The cover image was designed by Elizabeth Gutierrez. We want to thank all members of the Ntziachristos laboratory for their comments and critical review of the manuscript. All figures were created using BioRender (https://biorender.com/). The cover image was designed by Elizabeth Gutierrez (behance.net/elizabegutirr1). B.T.G-D. was supported in part by the US Department of State and COMEXUS via a Fulbright Garcia-Robles scholarship and by an NIH/NCI training grant (T32 CA009560). Related work in the Ntziachristos laboratory has been supported by the National Cancer Institute (R00CA188293), the Leukemia Research Foundation, the St. Baldrick's Foundation, the Zell Foundation, and the Elsa U. Pardee Foundation. The cover image was designed by Elizabeth Gutierrez. We want to thank all members of the Ntziachristos laboratory for their comments and critical review of the manuscript. All figures were created using BioRender ( https://biorender.com/ ). The cover image was designed by Elizabeth Gutierrez (behance.net/elizabegutirr1). B.T.G-D. was supported in part by the US Department of State and COMEXUS via a Fulbright Garcia-Robles scholarship and by an NIH/NCI training grant (T32 CA009560). Related work in the Ntziachristos laboratory has been supported by the National Cancer Institute ( R00CA188293 ), the Leukemia Research Foundation , the St. Baldrick\u2019s Foundation, the Zell Foundation, and the Elsa U. Pardee Foundation.

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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