Deubiquitinases: Pro-oncogenic Activity and Therapeutic Targeting in Blood Malignancies

Blanca T. Gutierrez-Diaz, Wei Gu, Panagiotis Ntziachristos*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

Deubiquitinases are enzymes that remove ubiquitin moieties from the vast majority of cellular proteins, controlling their stability, interactions, and localization. The expression and activity of deubiquitinases are critical for physiology and can go awry in various diseases, including cancer. Based on recent findings in human blood cancers, we discuss the functions of selected deubiquitinases in acute leukemia and efforts to target these enzymes with the aim of blocking leukemia growth and improving disease outcomes. We focus on the emergence of the newest generation of preclinical inhibitors by discussing their modes of inhibition and their effects on leukemia biology.

Original languageEnglish (US)
Pages (from-to)327-340
Number of pages14
JournalTrends in Immunology
Volume41
Issue number4
DOIs
StatePublished - Apr 2020

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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