Devastating sequelae of alloimmune thrombocytopenia: An entity that deserves more attention

Adib N. Khouzami*, Thomas S. Kickler, Nancy A. Callan, Joseph B. Shumway, Elizabeth J. Perlman, Karin J. Blakemore

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

In alloimmune thrombocytopenia, maternal sensitization to a fetal platelet alloantigen results in fetal thrombocytopenia. Even in primipara, 20% of offspring can suffer intracranial hemorrhage, half of which occur in utero. Ninety percent of subsequent pregnancies will be equally or more severely affected. We describe two patients whose previous pregnancies were complicated by neonatal alloimmune thrombocytopenia (NAIT). As expected, NAIT recurred, with devastating sequelae in both cases. One case presented with hydrops fetalis, a previously unreported association; the other fetus developed extensive intracranial hemorrhages in utero. Because both previous obstetrical histories had gone unrecognized, no preventative strategies had been undertaken. Conclusion: Better recognition of this disease through a positive obstetrical history is needed in order to properly counsel patients and institute appropriate prenatal treatment regimens.

Original languageEnglish (US)
Pages (from-to)137-141
Number of pages5
JournalJournal of Maternal-Fetal and Neonatal Medicine
Volume5
Issue number3
DOIs
StatePublished - 1996

Keywords

  • Alloimmune thrombocytopenia
  • Hydrops fetalis
  • Intracranial hemorrhage
  • Platelet disorder

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

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