Developing a valid patient-reported outcome measure

N. E. Rothrock*, K. A. Kaiser, D. Cella

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

134 Scopus citations


Many aspects of patients' experiences with illness, medication, and health care are best captured from patient-reported outcomes (PROs). In this article, we describe the process for constructing quality PRO instruments, from conceptual model development through instrument validation. We also discuss PROs as clinical trial end points and the potential of PRO data for aiding clinicians and patients in choosing from among multiple therapeutic options. Finally, we provide an overview of some existing PRO instruments.

Original languageEnglish (US)
Pages (from-to)737-742
Number of pages6
JournalClinical pharmacology and therapeutics
Issue number5
StatePublished - Nov 2011

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology


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