TY - JOUR
T1 - Developing injectable nanomaterials to repair the heart
AU - Nguyen, Mary M.
AU - Gianneschi, Nathan C.
AU - Christman, Karen L.
N1 - Funding Information:
This work was supported by a NIH Director's Transformative Research Award ( HL117326 ) and the NHLBI ( HL113468 ). We would also like to acknowledge Dr. Roberto Gaetani, Dr. Andrea Luthi, Jean Wang, and Jessica Ungerleider for their valuable input during the preparation of this review. Dr. Christman is co-founder, board member, and holds equity interest in Ventrix, Inc.
Publisher Copyright:
© 2015 Elsevier Ltd.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2015/8/1
Y1 - 2015/8/1
N2 - Injectable nanomaterials have been designed for the treatment of myocardial infarction, particularly during the acute stages of inflammation and injury. Among these strategies, injectable nanofibrous hydrogel networks or nanoparticle complexes may be delivered alone or with a therapeutic to improve heart function. Intramyocardial delivery of these materials localizes treatments to the site of injury. As an alternative, nanoparticles may be delivered intravenously, which provides the ultimate minimally invasive approach. These systems take advantage of the leaky vasculature after myocardial infarction, and may be designed to specifically target the injured region. The translational applicability of both intramyocardial and intravenous applications may provide safe and effective solutions upon optimizing the timing of the treatments and biodistribution.
AB - Injectable nanomaterials have been designed for the treatment of myocardial infarction, particularly during the acute stages of inflammation and injury. Among these strategies, injectable nanofibrous hydrogel networks or nanoparticle complexes may be delivered alone or with a therapeutic to improve heart function. Intramyocardial delivery of these materials localizes treatments to the site of injury. As an alternative, nanoparticles may be delivered intravenously, which provides the ultimate minimally invasive approach. These systems take advantage of the leaky vasculature after myocardial infarction, and may be designed to specifically target the injured region. The translational applicability of both intramyocardial and intravenous applications may provide safe and effective solutions upon optimizing the timing of the treatments and biodistribution.
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U2 - 10.1016/j.copbio.2015.03.016
DO - 10.1016/j.copbio.2015.03.016
M3 - Review article
C2 - 25863496
AN - SCOPUS:84926651838
SN - 0958-1669
VL - 34
SP - 225
EP - 231
JO - Current Opinion in Biotechnology
JF - Current Opinion in Biotechnology
ER -