Developing injectable nanomaterials to repair the heart

Mary M. Nguyen; Nathan C. Gianneschi; Karen L. Christman

doi:10.1016/j.copbio.2015.03.016

Developing injectable nanomaterials to repair the heart

Mary M. Nguyen, Nathan C. Gianneschi, Karen L. Christman^*

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Review article › peer-review

54 Scopus citations

Abstract

Injectable nanomaterials have been designed for the treatment of myocardial infarction, particularly during the acute stages of inflammation and injury. Among these strategies, injectable nanofibrous hydrogel networks or nanoparticle complexes may be delivered alone or with a therapeutic to improve heart function. Intramyocardial delivery of these materials localizes treatments to the site of injury. As an alternative, nanoparticles may be delivered intravenously, which provides the ultimate minimally invasive approach. These systems take advantage of the leaky vasculature after myocardial infarction, and may be designed to specifically target the injured region. The translational applicability of both intramyocardial and intravenous applications may provide safe and effective solutions upon optimizing the timing of the treatments and biodistribution.

Original language	English (US)
Pages (from-to)	225-231
Number of pages	7
Journal	Current Opinion in Biotechnology
Volume	34
DOIs	https://doi.org/10.1016/j.copbio.2015.03.016
State	Published - Aug 1 2015

Funding

This work was supported by a NIH Director's Transformative Research Award ( HL117326 ) and the NHLBI ( HL113468 ). We would also like to acknowledge Dr. Roberto Gaetani, Dr. Andrea Luthi, Jean Wang, and Jessica Ungerleider for their valuable input during the preparation of this review. Dr. Christman is co-founder, board member, and holds equity interest in Ventrix, Inc.

ASJC Scopus subject areas

Bioengineering
Biotechnology
Biomedical Engineering

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.copbio.2015.03.016

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abstract = "Injectable nanomaterials have been designed for the treatment of myocardial infarction, particularly during the acute stages of inflammation and injury. Among these strategies, injectable nanofibrous hydrogel networks or nanoparticle complexes may be delivered alone or with a therapeutic to improve heart function. Intramyocardial delivery of these materials localizes treatments to the site of injury. As an alternative, nanoparticles may be delivered intravenously, which provides the ultimate minimally invasive approach. These systems take advantage of the leaky vasculature after myocardial infarction, and may be designed to specifically target the injured region. The translational applicability of both intramyocardial and intravenous applications may provide safe and effective solutions upon optimizing the timing of the treatments and biodistribution.",

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AB - Injectable nanomaterials have been designed for the treatment of myocardial infarction, particularly during the acute stages of inflammation and injury. Among these strategies, injectable nanofibrous hydrogel networks or nanoparticle complexes may be delivered alone or with a therapeutic to improve heart function. Intramyocardial delivery of these materials localizes treatments to the site of injury. As an alternative, nanoparticles may be delivered intravenously, which provides the ultimate minimally invasive approach. These systems take advantage of the leaky vasculature after myocardial infarction, and may be designed to specifically target the injured region. The translational applicability of both intramyocardial and intravenous applications may provide safe and effective solutions upon optimizing the timing of the treatments and biodistribution.

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Developing injectable nanomaterials to repair the heart

Abstract

Funding

ASJC Scopus subject areas

UN SDGs

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