TY - JOUR
T1 - Development and cancer
T2 - At the crossroads of Nodal and Notch signaling
AU - Strizzi, Luigi
AU - Hardy, Katharine M.
AU - Seftor, Elisabeth A.
AU - Costa, Fabricio F.
AU - Kirschmann, Dawn A.
AU - Seftor, Richard E.B.
AU - Postovit, Lynne Marie
AU - Hendrix, Mary J.C.
PY - 2009
Y1 - 2009
N2 - Aggressive tumor cells express a plastic, multipotent phenotype similar to embryonic stem cells. However, the absence of major regulatory checkpoints in these tumor cells allows aberrant activation of embryonic signaling pathways, which seems to contribute to their plastic phenotype. Emerging evidence showing the molecular cross-talk between two major stem cell signaling pathways Nodal and Notch suggests a promising therapeutic strategy that could target aggressive tumor cells on the basis of their unique plasticity, and provide new insights into the mechanisms underlying the reemergence of developmental signaling pathways during tumor progression.
AB - Aggressive tumor cells express a plastic, multipotent phenotype similar to embryonic stem cells. However, the absence of major regulatory checkpoints in these tumor cells allows aberrant activation of embryonic signaling pathways, which seems to contribute to their plastic phenotype. Emerging evidence showing the molecular cross-talk between two major stem cell signaling pathways Nodal and Notch suggests a promising therapeutic strategy that could target aggressive tumor cells on the basis of their unique plasticity, and provide new insights into the mechanisms underlying the reemergence of developmental signaling pathways during tumor progression.
UR - http://www.scopus.com/inward/record.url?scp=70349751655&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=70349751655&partnerID=8YFLogxK
U2 - 10.1158/0008-5472.CAN-09-1199
DO - 10.1158/0008-5472.CAN-09-1199
M3 - Review article
C2 - 19738053
AN - SCOPUS:70349751655
SN - 0008-5472
VL - 69
SP - 7131
EP - 7134
JO - Cancer Research
JF - Cancer Research
IS - 18
ER -
