Development and evaluation of a high performance T1-weighted brain template for use in studies on older adults

Alzheimer's Disease Neuroimaging Initiative

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Τhe accuracy of template-based neuroimaging investigations depends on the template's image quality and representativeness of the individuals under study. Yet a thorough, quantitative investigation of how available standardized and study-specific T1-weighted templates perform in studies on older adults has not been conducted. The purpose of this work was to construct a high-quality standardized T1-weighted template specifically designed for the older adult brain, and systematically compare the new template to several other standardized and study-specific templates in terms of image quality, performance in spatial normalization of older adult data and detection of small inter-group morphometric differences, and representativeness of the older adult brain. The new template was constructed with state-of-the-art spatial normalization of high-quality data from 222 older adults. It was shown that the new template (a) exhibited high image sharpness, (b) provided higher inter-subject spatial normalization accuracy and (c) allowed detection of smaller inter-group morphometric differences compared to other standardized templates, (d) had similar performance to that of study-specific templates constructed with the same methodology, and (e) was highly representative of the older adult brain.

Original languageEnglish (US)
Pages (from-to)1758-1776
Number of pages19
JournalHuman Brain Mapping
Issue number6
StatePublished - Apr 15 2021


  • aging
  • atlas
  • brain
  • magnetic resonance imaging
  • spatial normalization
  • template

ASJC Scopus subject areas

  • Anatomy
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Clinical Neurology


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