Development and validation of an ankle brachial index risk model for the prediction of cardiovascular events

F. G.R. Fowkes*, G. D. Murray, I. Butcher, A. R. Folsom, A. T. Hirsch, D. J. Couper, G. Debacker, M. Kornitzer, A. B. Newman, K. C. Sutton-Tyrrell, M. Cushman, A. J. Lee, J. F. Price, R. B. D'Agostino, J. M. Murabito, P. E. Norman, K. H. Masaki, L. M. Bouter, R. J. Heine, C. D.A. StehouwerM. M. McDermott, H. E.J.H. Stoffers, J. A. Knottnerus, M. Ogren, B. Hedblad, W. Koenig, C. Meisinger, J. A. Cauley, O. H. Franco, M. G.M. Hunink, A. Hofman, J. C. Witteman, M. H. Criqui, R. D. Langer, W. R. Hiatt, R. F. Hamman

*Corresponding author for this work

Research output: Contribution to journalArticle

44 Scopus citations

Abstract

Background: The ankle brachial index (ABI) is related to risk of cardiovascular events independent of the Framingham risk score (FRS). The aim of this study was to develop and evaluate a risk model for cardiovascular events incorporating the ABI and FRS. Design: An analysis of participant data from 18 cohorts in which 24,375 men and 20,377 women free of coronary heart disease had ABI measured and were followed up for events. Methods: Subjects were divided into a development and internal validation dataset and an external validation dataset. Two models, comprising FRS and FRS+ABI, were fitted for the primary outcome of major coronary events.

Original languageEnglish (US)
Pages (from-to)310-320
Number of pages11
JournalEuropean journal of preventive cardiology
Volume21
Issue number3
DOIs
StatePublished - Mar 2014

Keywords

  • Ankle brachial index
  • cardiovascular diseases
  • risk assessment

ASJC Scopus subject areas

  • Epidemiology
  • Cardiology and Cardiovascular Medicine

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    Fowkes, F. G. R., Murray, G. D., Butcher, I., Folsom, A. R., Hirsch, A. T., Couper, D. J., Debacker, G., Kornitzer, M., Newman, A. B., Sutton-Tyrrell, K. C., Cushman, M., Lee, A. J., Price, J. F., D'Agostino, R. B., Murabito, J. M., Norman, P. E., Masaki, K. H., Bouter, L. M., Heine, R. J., ... Hamman, R. F. (2014). Development and validation of an ankle brachial index risk model for the prediction of cardiovascular events. European journal of preventive cardiology, 21(3), 310-320. https://doi.org/10.1177/2047487313516564