Development and validation of an ankle brachial index risk model for the prediction of cardiovascular events

F. G.R. Fowkes; G. D. Murray; I. Butcher; A. R. Folsom; A. T. Hirsch; D. J. Couper; G. Debacker; M. Kornitzer; A. B. Newman; K. C. Sutton-Tyrrell; M. Cushman; A. J. Lee; J. F. Price; R. B. D'Agostino; J. M. Murabito; P. E. Norman; K. H. Masaki; L. M. Bouter; R. J. Heine; C. D.A. Stehouwer; M. M. McDermott; H. E.J.H. Stoffers; J. A. Knottnerus; M. Ogren; B. Hedblad; W. Koenig; C. Meisinger; J. A. Cauley; O. H. Franco; M. G.M. Hunink; A. Hofman; J. C. Witteman; M. H. Criqui; R. D. Langer; W. R. Hiatt; R. F. Hamman

doi:10.1177/2047487313516564

Development and validation of an ankle brachial index risk model for the prediction of cardiovascular events

F. G.R. Fowkes^*, G. D. Murray, I. Butcher, A. R. Folsom, A. T. Hirsch, D. J. Couper, G. Debacker, M. Kornitzer, A. B. Newman, K. C. Sutton-Tyrrell, M. Cushman, A. J. Lee, J. F. Price, R. B. D'Agostino, J. M. Murabito, P. E. Norman, K. H. Masaki, L. M. Bouter, R. J. Heine, C. D.A. StehouwerM. M. McDermott, H. E.J.H. Stoffers, J. A. Knottnerus, M. Ogren, B. Hedblad, W. Koenig, C. Meisinger, J. A. Cauley, O. H. Franco, M. G.M. Hunink, A. Hofman, J. C. Witteman, M. H. Criqui, R. D. Langer, W. R. Hiatt, R. F. Hamman

^*Corresponding author for this work

Medicine, General Medicine Division

Research output: Contribution to journal › Article

44 Scopus citations

Abstract

Background: The ankle brachial index (ABI) is related to risk of cardiovascular events independent of the Framingham risk score (FRS). The aim of this study was to develop and evaluate a risk model for cardiovascular events incorporating the ABI and FRS. Design: An analysis of participant data from 18 cohorts in which 24,375 men and 20,377 women free of coronary heart disease had ABI measured and were followed up for events. Methods: Subjects were divided into a development and internal validation dataset and an external validation dataset. Two models, comprising FRS and FRS+ABI, were fitted for the primary outcome of major coronary events.

Original language	English (US)
Pages (from-to)	310-320
Number of pages	11
Journal	European journal of preventive cardiology
Volume	21
Issue number	3
DOIs	https://doi.org/10.1177/2047487313516564
State	Published - Mar 2014

Keywords

Ankle brachial index
cardiovascular diseases
risk assessment

ASJC Scopus subject areas

Epidemiology
Cardiology and Cardiovascular Medicine

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Fowkes, F. G. R., Murray, G. D., Butcher, I., Folsom, A. R., Hirsch, A. T., Couper, D. J., Debacker, G., Kornitzer, M., Newman, A. B., Sutton-Tyrrell, K. C., Cushman, M., Lee, A. J., Price, J. F., D'Agostino, R. B., Murabito, J. M., Norman, P. E., Masaki, K. H., Bouter, L. M., Heine, R. J., ... Hamman, R. F. (2014). Development and validation of an ankle brachial index risk model for the prediction of cardiovascular events. European journal of preventive cardiology, 21(3), 310-320. https://doi.org/10.1177/2047487313516564

Fowkes, F. G.R. ; Murray, G. D. ; Butcher, I. ; Folsom, A. R. ; Hirsch, A. T. ; Couper, D. J. ; Debacker, G. ; Kornitzer, M. ; Newman, A. B. ; Sutton-Tyrrell, K. C. ; Cushman, M. ; Lee, A. J. ; Price, J. F. ; D'Agostino, R. B. ; Murabito, J. M. ; Norman, P. E. ; Masaki, K. H. ; Bouter, L. M. ; Heine, R. J. ; Stehouwer, C. D.A. ; McDermott, M. M. ; Stoffers, H. E.J.H. ; Knottnerus, J. A. ; Ogren, M. ; Hedblad, B. ; Koenig, W. ; Meisinger, C. ; Cauley, J. A. ; Franco, O. H. ; Hunink, M. G.M. ; Hofman, A. ; Witteman, J. C. ; Criqui, M. H. ; Langer, R. D. ; Hiatt, W. R. ; Hamman, R. F. / Development and validation of an ankle brachial index risk model for the prediction of cardiovascular events. In: European journal of preventive cardiology. 2014 ; Vol. 21, No. 3. pp. 310-320.

@article{1b065b44d5f24bdc81265ab0ae876450,

title = "Development and validation of an ankle brachial index risk model for the prediction of cardiovascular events",

abstract = "Background: The ankle brachial index (ABI) is related to risk of cardiovascular events independent of the Framingham risk score (FRS). The aim of this study was to develop and evaluate a risk model for cardiovascular events incorporating the ABI and FRS. Design: An analysis of participant data from 18 cohorts in which 24,375 men and 20,377 women free of coronary heart disease had ABI measured and were followed up for events. Methods: Subjects were divided into a development and internal validation dataset and an external validation dataset. Two models, comprising FRS and FRS+ABI, were fitted for the primary outcome of major coronary events.",

keywords = "Ankle brachial index, cardiovascular diseases, risk assessment",

author = "Fowkes, {F. G.R.} and Murray, {G. D.} and I. Butcher and Folsom, {A. R.} and Hirsch, {A. T.} and Couper, {D. J.} and G. Debacker and M. Kornitzer and Newman, {A. B.} and Sutton-Tyrrell, {K. C.} and M. Cushman and Lee, {A. J.} and Price, {J. F.} and D'Agostino, {R. B.} and Murabito, {J. M.} and Norman, {P. E.} and Masaki, {K. H.} and Bouter, {L. M.} and Heine, {R. J.} and Stehouwer, {C. D.A.} and McDermott, {M. M.} and Stoffers, {H. E.J.H.} and Knottnerus, {J. A.} and M. Ogren and B. Hedblad and W. Koenig and C. Meisinger and Cauley, {J. A.} and Franco, {O. H.} and Hunink, {M. G.M.} and A. Hofman and Witteman, {J. C.} and Criqui, {M. H.} and Langer, {R. D.} and Hiatt, {W. R.} and Hamman, {R. F.}",

year = "2014",

month = mar,

doi = "10.1177/2047487313516564",

language = "English (US)",

volume = "21",

pages = "310--320",

journal = "European Journal of Preventive Cardiology",

issn = "2047-4873",

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Fowkes, FGR, Murray, GD, Butcher, I, Folsom, AR, Hirsch, AT, Couper, DJ, Debacker, G, Kornitzer, M, Newman, AB, Sutton-Tyrrell, KC, Cushman, M, Lee, AJ, Price, JF, D'Agostino, RB, Murabito, JM, Norman, PE, Masaki, KH, Bouter, LM, Heine, RJ, Stehouwer, CDA, McDermott, MM, Stoffers, HEJH, Knottnerus, JA, Ogren, M, Hedblad, B, Koenig, W, Meisinger, C, Cauley, JA, Franco, OH, Hunink, MGM, Hofman, A, Witteman, JC, Criqui, MH, Langer, RD, Hiatt, WR & Hamman, RF 2014, 'Development and validation of an ankle brachial index risk model for the prediction of cardiovascular events', European journal of preventive cardiology, vol. 21, no. 3, pp. 310-320. https://doi.org/10.1177/2047487313516564

Development and validation of an ankle brachial index risk model for the prediction of cardiovascular events. / Fowkes, F. G.R.; Murray, G. D.; Butcher, I.; Folsom, A. R.; Hirsch, A. T.; Couper, D. J.; Debacker, G.; Kornitzer, M.; Newman, A. B.; Sutton-Tyrrell, K. C.; Cushman, M.; Lee, A. J.; Price, J. F.; D'Agostino, R. B.; Murabito, J. M.; Norman, P. E.; Masaki, K. H.; Bouter, L. M.; Heine, R. J.; Stehouwer, C. D.A.; McDermott, M. M.; Stoffers, H. E.J.H.; Knottnerus, J. A.; Ogren, M.; Hedblad, B.; Koenig, W.; Meisinger, C.; Cauley, J. A.; Franco, O. H.; Hunink, M. G.M.; Hofman, A.; Witteman, J. C.; Criqui, M. H.; Langer, R. D.; Hiatt, W. R.; Hamman, R. F.

In: European journal of preventive cardiology, Vol. 21, No. 3, 03.2014, p. 310-320.

Research output: Contribution to journal › Article

TY - JOUR

T1 - Development and validation of an ankle brachial index risk model for the prediction of cardiovascular events

AU - Fowkes, F. G.R.

AU - Murray, G. D.

AU - Butcher, I.

AU - Folsom, A. R.

AU - Hirsch, A. T.

AU - Couper, D. J.

AU - Debacker, G.

AU - Kornitzer, M.

AU - Newman, A. B.

AU - Sutton-Tyrrell, K. C.

AU - Cushman, M.

AU - Lee, A. J.

AU - Price, J. F.

AU - D'Agostino, R. B.

AU - Murabito, J. M.

AU - Norman, P. E.

AU - Masaki, K. H.

AU - Bouter, L. M.

AU - Heine, R. J.

AU - Stehouwer, C. D.A.

AU - McDermott, M. M.

AU - Stoffers, H. E.J.H.

AU - Knottnerus, J. A.

AU - Ogren, M.

AU - Hedblad, B.

AU - Koenig, W.

AU - Meisinger, C.

AU - Cauley, J. A.

AU - Franco, O. H.

AU - Hunink, M. G.M.

AU - Hofman, A.

AU - Witteman, J. C.

AU - Criqui, M. H.

AU - Langer, R. D.

AU - Hiatt, W. R.

AU - Hamman, R. F.

PY - 2014/3

Y1 - 2014/3

N2 - Background: The ankle brachial index (ABI) is related to risk of cardiovascular events independent of the Framingham risk score (FRS). The aim of this study was to develop and evaluate a risk model for cardiovascular events incorporating the ABI and FRS. Design: An analysis of participant data from 18 cohorts in which 24,375 men and 20,377 women free of coronary heart disease had ABI measured and were followed up for events. Methods: Subjects were divided into a development and internal validation dataset and an external validation dataset. Two models, comprising FRS and FRS+ABI, were fitted for the primary outcome of major coronary events.

AB - Background: The ankle brachial index (ABI) is related to risk of cardiovascular events independent of the Framingham risk score (FRS). The aim of this study was to develop and evaluate a risk model for cardiovascular events incorporating the ABI and FRS. Design: An analysis of participant data from 18 cohorts in which 24,375 men and 20,377 women free of coronary heart disease had ABI measured and were followed up for events. Methods: Subjects were divided into a development and internal validation dataset and an external validation dataset. Two models, comprising FRS and FRS+ABI, were fitted for the primary outcome of major coronary events.

KW - Ankle brachial index

KW - cardiovascular diseases

KW - risk assessment

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DO - 10.1177/2047487313516564

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EP - 320

JO - European Journal of Preventive Cardiology

JF - European Journal of Preventive Cardiology

SN - 2047-4873

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