Development and validation of the functional assessment of cancer therapy nasopharyngeal cancer subscale

Michael C.F. Tong, Phoebe S.Y. Lo, Hung Wong Kam, Rebecca M.W. Yeung, C. Andrew Van Hasselt, Sonya Eremenco, David Cella

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Background. We aimed to develop a quality-of-life subscale for nasopharyngeal carcinoma (NPC) and validate the functional assessment of cancer therapy-nasopharyngeal (FACT-NP). Methods. The FACT-NP was tested cross-sectionally in survivors of postirradiated NPC (n = 357) and was administered to newly diagnosed patients (n = 160) before, at the end of, and 3 months after radiotherapy (RT). Results. Each FACT-NP domain was internally consistent (Cronbach's alpha = 0.87-0.90). The test-retest reliability for each subscale was satisfactory (intraclass correlation coefficient = .73-.88). Concurrent validity was suggested by the moderate to strong correlations between the FACT-NP and the Quality of Life-Radiation Therapy Instrument-Head and Neck (QOL-RTI-H&N) subscales (Pearson r = .39-.84). The FACT-NP was responsive to clinical changes from pretreatment to 3 months after RT (effect sizes > 0.6 for clinically relevant subscales). The pooled data for multitrait scaling analysis showed satisfactory item internal consistency and item discriminant validity (100% and 90% scaling success, respectively). Conclusion. The FACT-NP is a reliable and valid instrument for measuring QOL in patients with NPC.

Original languageEnglish (US)
Pages (from-to)738-747
Number of pages10
JournalHead and Neck
Issue number6
StatePublished - Jun 1 2009


  • Clinical outcome
  • Functional assessment
  • Nasopharyngeal carcinoma
  • Quality of life
  • Radiation therapy

ASJC Scopus subject areas

  • Otorhinolaryngology


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