Development from the fertilized egg to the three germ layers and its relevance to signaling and lineage commitment of embryonic stem cells

Paul Burridge, Kenneth R. Boheler*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

In this chapter we cover developmental biology of murine development from the fertilized egg to lineage commitment and specification of the three germ layers. Post-fertilization processes including pluripotency, pre-and post-implantation development and axis specification are discussed in detail. We go on to discuss the role of the Tgf-Β, Nodal, Activin, Bmp, Fgf.

Original languageEnglish (US)
Title of host publicationStem Cells
Subtitle of host publicationFrom Basic Research to Therapy, Volume 1: Basic Stem Cell Biology, Tissue Formation during Development, and Model Organisms
PublisherCRC Press
Pages151-184
Number of pages34
ISBN (Electronic)9781482207767
ISBN (Print)9781482207750
DOIs
StatePublished - Jan 1 2014

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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