Development of a bioengineered tissue model and its application in the investigation of the depth selectivity of polarization gating

Yang Liu*, Young L. Kim, Vadim Backman

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Understanding the propagation of polarized light in tissue is crucial for a number of biomédical optics applications. Here we report the development of a bioengineered connective tissue model fabricated by the combination of scaffolding and cross-linking techniques to study light transport in biological tissue. It demonstrates great similarity to real connective tissue in its optical properties as well as microarchitecture. Moreover, the optical properties of the model can be reproducibly controlled. As an example, we report the utilization of this model to study the effect of epithelium and the underlying connective tissue on the depth selectivity of polarization gating.

Original languageEnglish (US)
Pages (from-to)2288-2299
Number of pages12
JournalApplied optics
Volume44
Issue number12
DOIs
StatePublished - Apr 20 2005

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Engineering (miscellaneous)
  • Electrical and Electronic Engineering

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