Development of a chemical retinal prosthesis: Stimulation of rat retina with glutamate

Corey M. Rountree, Samsoon Inayat, John B. Troy, Laxman Saggere

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

Retinal degenerative diseases cause partial or total blindness and affect millions of people worldwide, yet currently have no treatment. Retinal prostheses using electrical stimulation are being developed but face significant problems moving forward. Here we propose using chemical stimulation, via the neurotransmitter glutamate, to modulate retinal ganglion cell (RGC) spike rates. Our results demonstrate that it is feasible to stimulate RGCs in an explanted retina using focal ejections of glutamate from either subretinal or epiretinal sides. Preliminary evidence suggests we are primarily activating RGCs as opposed to bipolar cells. This is an important first step in the development of a chemical retinal prosthesis based on microelectromechanical systems (MEMS) technology.

Original languageEnglish (US)
Title of host publication2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013
Pages3134-3137
Number of pages4
DOIs
StatePublished - Oct 31 2013
Event2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013 - Osaka, Japan
Duration: Jul 3 2013Jul 7 2013

Publication series

NameProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
ISSN (Print)1557-170X

Other

Other2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013
CountryJapan
CityOsaka
Period7/3/137/7/13

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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    Rountree, C. M., Inayat, S., Troy, J. B., & Saggere, L. (2013). Development of a chemical retinal prosthesis: Stimulation of rat retina with glutamate. In 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013 (pp. 3134-3137). [6610205] (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). https://doi.org/10.1109/EMBC.2013.6610205