Development of a conceptual framework and calibrated item banks to measure patient-reported dyspnea severity and related functional limitations

Seung W. Choi, David E. Victorson, Susan Yount, Susan Anton, David Cella

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

Objectives: Chronic obstructive pulmonary disease is a major global health problem. Although several patient-reported outcome (PRO) measures of chronic obstructive pulmonary disease exist, none were developed using patient-driven concept development. We developed an item bank for dyspnea severity and related functional limitations on the basis of a PRO conceptual framework derived from patient input. Methods: We identified a large pool of existing items based on a conceptual framework and literature review. Using patient and expert review panels and an item refinement/modification process, we developed an item bank aligned with the conceptual framework, which subsequently underwent psychometric testing via an online Internet panel of dyspnea patients (N = 608). Results: Exploratory factor analysis suggested a dominant first factor accounting for about 78% of the total variance. Confirmatory factor analysis supported a unidimensional model. Item response theory analysis demonstrated good model fit, and differential item functioning analyses indicated that the 33-item scale showed potential for measurement equivalence across sex. A 10-item short form produced comparable scores (r = 0.98) and a computerized adaptive-testing simulation indicated efficient measurement with fewer items (mean 4.65 items). Conclusions: An efficient patient-reported measure of dyspnea severity and related functional limitations, based on a patient-driven PRO conceptual framework, is now available for further validation and use.

Original languageEnglish (US)
Pages (from-to)291-306
Number of pages16
JournalValue in Health
Volume14
Issue number2
DOIs
StatePublished - 2011

Funding

Funding: This work was supported in part by a grant from Boehringer Ingelheim Pharmaceuticals .

Keywords

  • COPD
  • Computer adaptive testing
  • Dyspnea
  • Measurement
  • Scale development

ASJC Scopus subject areas

  • Health Policy
  • Public Health, Environmental and Occupational Health

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