Development of a core outcome set for basal cell carcinoma

Daniel I. Schlessinger, Kelly A. Reynolds, McKenzie A. Dirr, Sarah A. Ibrahim, Arianna F. Yanes, Jake M. Lazaroff, Victoria Godinez-Puig, Brian R. Chen, Anastasia O. Kurta, Jill K. Cotseones, Sarah G. Chiren, Karina C. Furlan, Sanjana Iyengar, Ramona Behshad, Danielle M. DeHoratius, Pablo Denes, Aaron M. Drucker, Leonard M. Dzubow, Jeremy R. Etzkorn, Catherine A. HarwoodJohn Y.S. Kim, Naomi Lawrence, Erica H. Lee, Gary S. Lissner, Ashfaq A. Marghoob, Rubeta N. Matin, Adam R. Mattox, Bharat B. Mittal, J. Regan Thomas, Xiaolong Alan Zhou, David Zloty, Jochen Schmitt, Jamie J. Kirkham, April W. Armstrong, Nicole Basset-Seguin, Elizabeth M. Billingsley, Jeremy S. Bordeaux, Jerry Brewer, Marc Brown, Mariah Brown, Scott A.B. Collins, Maria Concetta Fargnoli, Sergio Jobim De Azevedo, Reinhard Dummer, Alexander Eggermont, Glenn D. Goldman, Merete Haedersdal, Elizabeth K. Hale, Allison Hanlon, Kelly L. Harms, Conway C. Huang, Eva A. Hurst, Gino K. In, Nicole Kelleners-Smeets, Meenal Kheterpal, Barry Leshin, Michel Mcdonald, Stanley J. Miller, Alexander Miller, Eliot N. Mostow, Myrto Trakatelli, Kishwer S. Nehal, Desiree Ratner, Howard Rogers, Kavita Y. Sarin, Seaver L. Soon, Thomas Stasko, Paul A. Storrs, Luca Tagliaferri, Allison T. Vidimos, Sandra L. Wong, Siegrid S. Yu, Iris Zalaudek, Nathalie C. Zeitouni, John A. Zitelli, Emily Poon, Joseph F. Sobanko, Todd V. Cartee, Ian A. Maher, Murad Alam*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Background: There is variation in the outcomes reported in clinical studies of basal cell carcinoma. This can prevent effective meta-analyses from answering important clinical questions. Objective: To identify a recommended minimum set of core outcomes for basal cell carcinoma clinical trials. Methods: Patient and professional Delphi process to cull a long list, culminating in a consensus meeting. To be provisionally accepted, outcomes needed to be deemed important (score, 7-9, with 9 being the maximum) by 70% of each stakeholder group. Results: Two hundred thirty-five candidate outcomes identified via a systematic literature review and survey of key stakeholders were reduced to 74 that were rated by 100 health care professionals and patients in 2 Delphi rounds. Twenty-seven outcomes were provisionally accepted. The final core set of 5 agreed-upon outcomes after the consensus meeting included complete response; persistent or serious adverse events; recurrence-free survival; quality of life; and patient satisfaction, including cosmetic outcome. Limitations: English-speaking patients and professionals rated outcomes extracted from English language studies. Conclusion: A core outcome set for basal cell carcinoma has been developed. The use of relevant measures may improve the utility of clinical research and the quality of therapeutic guidance available to clinicians.

Original languageEnglish (US)
Pages (from-to)573-581
Number of pages9
JournalJournal of the American Academy of Dermatology
Volume87
Issue number3
DOIs
StatePublished - Sep 2022

Keywords

  • basal cell carcinoma
  • core
  • measure
  • outcome
  • set
  • skin cancer

ASJC Scopus subject areas

  • Dermatology

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